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HPD Knockout Cell Lines

Gene: HPD

Official Full Name: 4-hydroxyphenylpyruvate dioxygenaseprovided by HGNC

Gene Summary: The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37214 HPD Knockout cell line (HeLa) Human HPD 1:3~1:6 Negative Online Inquiry
KO37215 HPD Knockout cell line (HEK293) Human HPD 1:3~1:6 Negative Online Inquiry
KO37216 HPD Knockout cell line (A549) Human HPD 1:3~1:4 Negative Online Inquiry

Background

HPD Gene Knockout Cell Lines are specialized genetic models engineered to lack the expression of the hyaluronic acid synthase 2 (HPD) gene. These cell lines are generated through the use of advanced gene-editing technologies, such as CRISPR-Cas9, which allows for precise modifications to the genomic DNA of the target cells. By knocking out the HPD gene, researchers can examine the resulting cellular and physiological changes, thereby illuminating the role of hyaluronic acid in various biological processes, including cancer progression, wound healing, and inflammatory responses.

The primary function of HPD Gene Knockout Cell Lines is to serve as a valuable tool for in vitro studies focused on understanding the implications of hyaluronic acid signaling pathways. The absence of the HPD gene provides insights into cellular behavior, enabling researchers to explore the relationship between hyaluronic acid levels and cellular mechanisms such as migration, proliferation, and differentiation. Furthermore, these knockout lines can be employed in drug discovery and toxicology assessments, where understanding the specific contributions of hyaluronic acid is crucial.

From a scientific perspective, the use of HPD Gene Knockout Cell Lines holds significant promise in fields such as cancer research and regenerative medicine, where hyaluronic acid plays a central role. The ability to utilize these models allows scientists to investigate potential therapeutic targets and interventions that may inhibit or modify hyaluronic acid production, ultimately leading to improved clinical outcomes.

Compared to traditional cell lines that express the HPD gene, these knockout variants provide a more distinct understanding of hyaluronic acid's role, which is often masked in wild-type models. Additionally, the precision of gene knockout technology reduces off-target effects that can skew experimental results, enhancing the reliability of research findings.

For researchers and clinicians seeking robust and innovative solutions in the study of hyaluronic acid biology, HPD Gene Knockout Cell Lines represent a cutting-edge resource. Their unique ability to provide clear, context-specific insights into molecular pathways makes them invaluable for advancing scientific knowledge and informing therapeutic strategies.

With extensive experience in producing high-quality biological models, our company is committed to supporting the needs of the research community by providing expertly characterized cell lines that facilitate groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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