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HOXD10 Knockout Cell Lines

Gene: HOXD10

Official Full Name: homeobox D10provided by HGNC

Gene Summary: This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05953 HOXD10 Knockout cell line (HEK293) Human HOXD10 1:3~1:6 Negative Online Inquiry
KO05954 HOXD10 Knockout cell line (A549) Human HOXD10 1:3~1:4 Negative Online Inquiry

Background

HOXD10 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the HOXD10 gene and its functional contributions to various biological processes. This gene is part of the homeobox gene family, which plays a pivotal role in regulating development, particularly in limb and spinal cord morphology. By employing CRISPR-Cas9 gene-editing technology, our knockout cell lines effectively eliminate the expression of the HOXD10 gene, enabling researchers to investigate the phenotypic and molecular consequences of its absence.

The primary mechanism of these cell lines involves the targeted disruption of the HOXD10 locus, which leads to the loss of mRNA production and, subsequently, the encoded protein. This gene disruption allows for an in-depth exploration of the gene's roles in cellular proliferation, differentiation, and potential implications in diseases such as cancer and developmental disorders. Researchers can utilize these knockout models to advance studies in gene function, pathway analysis, and drug discovery, paving the way for innovative therapeutic strategies.

Scientifically, the significance of HOXD10 Gene Knockout Cell Lines is underscored by their applications in functional genomics and regenerative medicine. By providing a reliable model system, they enable the dissection of complex genetic interactions and cellular responses, making them invaluable for translational research.

Unique selling points of our product include the purity of the knockout lines, which reduce background noise in experimental results, and the availability of multiple cell types derived from different tissues, expanding potential applications. Unlike other knockout models, our lines have undergone rigorous validation to ensure consistent performance across experiments, providing confidence in data reproducibility and integrity.

For researchers and clinicians, the ability to precisely modulate the HOXD10 gene is essential for advancing knowledge in developmental biology and potential clinical applications. These cell lines represent a critical resource for elucidating the mechanisms underlying gene function and the pathways that contribute to various pathologies.

With a strong foundation in biotechnology and extensive experience in developing high-quality biological products, our company is dedicated to empowering the research community with tools that enhance scientific discovery and innovation. Our commitment to excellence ensures that you receive reliable and effective solutions tailored to your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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