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HNRNPDL Knockout Cell Lines

Gene: HNRNPDL

Official Full Name: heterogeneous nuclear ribonucleoprotein D likeprovided by HGNC

Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32398 HNRNPDL Knockout cell line (HeLa) Human HNRNPDL 1:3~1:6 Negative Online Inquiry
KO32399 HNRNPDL Knockout cell line (HCT 116) Human HNRNPDL 1:2~1:4 Negative Online Inquiry
KO32400 HNRNPDL Knockout cell line (HEK293) Human HNRNPDL 1:3~1:6 Negative Online Inquiry
KO32401 HNRNPDL Knockout cell line (A549) Human HNRNPDL 1:3~1:4 Negative Online Inquiry

Background

HNRNPDL Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) gene. This particular protein is crucial in various cellular processes, including RNA splicing, transport, and post-transcriptional regulation. The knockout of HNRNPDL allows researchers to explore its physiological and pathological roles by observing the cellular effects of its absence.

These cell lines utilize CRISPR-Cas9 technology to ensure precise and efficient gene editing, resulting in a reliable model for investigating the mechanisms underlying the activities and interactions of HNRNPDL. Researchers can utilize these knockout models to study gene expression profiles, elucidate the gene's role in disease, and unlock new therapeutic pathways, particularly in cancers and neurodegenerative disorders where HNRNPDL has been shown to contribute to disease progression.

The scientific importance of HNRNPDL Gene Knockout Cell Lines extends across multiple research domains, enabling groundbreaking studies on RNA biology and cellular dynamics. Compared to traditional gene knockdown methods, these knockout cell lines provide a more stable and complete loss-of-function model, facilitating the investigation of gene function with increased specificity and reliability.

What sets our HNRNPDL Gene Knockout Cell Lines apart from alternatives is the stringent quality control measures taken during development, ensuring high knockout efficiency and minimal off-target effects. The ease of use and reproducibility of these models can significantly streamline experimental workflows, enhancing productivity and the potential for impactful discoveries.

Ultimately, our HNRNPDL Gene Knockout Cell Lines represent a valuable tool for researchers and clinicians looking to gain deeper insights into gene function and disease biology. The dedication of our company to advancing genetic research, combined with our expertise in providing high-quality biological products, positions us as a trusted partner in the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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