Home / HNRNPD Knockout Cell Lines

HNRNPD Knockout Cell Lines

Gene: HNRNPD

Official Full Name: heterogeneous nuclear ribonucleoprotein Dprovided by HGNC

Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37279 HNRNPD Knockout cell line (HeLa) Human HNRNPD 1:3~1:6 Negative Online Inquiry
KO37280 HNRNPD Knockout cell line (HCT 116) Human HNRNPD 1:2~1:4 Negative Online Inquiry
KO37281 HNRNPD Knockout cell line (HEK293) Human HNRNPD 1:3~1:6 Negative Online Inquiry
KO37282 HNRNPD Knockout cell line (A549) Human HNRNPD 1:3~1:4 Negative Online Inquiry

Background

HNRNPD Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the human heterogenous nuclear ribonucleoprotein D, commonly referred to as HNRNPD. This gene plays a crucial role in pre-mRNA processing and various aspects of RNA metabolism, influencing the regulation of gene expression and cellular stress responses. By employing CRISPR-Cas9 gene-editing technology, these knockout cell lines enable researchers to investigate the functional implications of HNRNPD loss, thereby illuminating its contribution to cellular pathways and disease states.

The primary mechanism through which HNRNPD functions involves its interaction with RNA molecules, where it associates with pre-mRNA and facilitates splicing, transport, and stability processes. Consequently, HNRNPD knockout cell lines can be integral to studying alternative splicing patterns, mRNA stability, and the cellular response to stressors. This is particularly crucial in research areas such as cancer biology, neurodegenerative diseases, and viral infections where alterations in RNA metabolism are prevalent.

Scientists highly value HNRNPD Gene Knockout Cell Lines because they provide a robust platform to elucidate the role of this gene in various biological contexts, thereby opening avenues for potential therapeutic interventions. Compared to traditional knockdown techniques, such as siRNA-mediated silencing, gene knockout offers a more complete disruption of HNRNPD function, allowing for clearer insights into its biological roles. Additionally, these cell lines are available in multiple backgrounds, providing flexibility for researchers seeking to replicate specific physiological conditions.

For researchers and clinicians striving to advance our understanding of RNA biology and its implications in health and disease, HNRNPD Gene Knockout Cell Lines present a powerful tool that facilitates groundbreaking research and innovative discoveries. Our commitment to excellence in producing high-quality biological products underscores our expertise and dedication to supporting the scientific community in its endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.