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HES7 Knockout Cell Lines

Gene: HES7

Official Full Name: hes family bHLH transcription factor 7provided by HGNC

Gene Summary: This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04372 HES7 Knockout cell line (HeLa) Human HES7 1:3~1:6 Negative Online Inquiry
KO04373 HES7 Knockout cell line (HEK293) Human HES7 1:3~1:6 Negative Online Inquiry

Background

HES7 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the HES7 gene, known for its critical role in the regulation of neurogenesis and somite segmentation during embryonic development. These cell lines are generated using advanced CRISPR/Cas9 technology to precisely disrupt the HES7 gene, allowing researchers to investigate the gene's functions and its contribution to various biological processes in vitro.

The primary function of the HES7 Gene Knockout Cell Lines lies in their ability to elucidate the molecular pathways mediated by HES7. By creating a knockout model, researchers can assess the downstream effects of HES7 loss on cellular behavior, differentiation, and proliferation. The cell lines serve as powerful tools for studying developmental biology and genetic regulation, providing insights into conditions such as congenital disorders and cancer.

From a scientific perspective, these cell lines are invaluable in both research and clinical settings. They can be utilized to screen potential therapeutic compounds, identify modulators of the HES7-related pathways, and serve as a platform for gene therapy approaches. Additionally, the models facilitate high-throughput screening processes, accelerating the pace of discovery in molecular biology and genetics.

A distinctive advantage of HES7 Gene Knockout Cell Lines compared to traditional models is their precision and efficiency in gene editing, which significantly reduces the risk of off-target effects. Unlike alternative models that might still express residual HES7, these cell lines exhibit clear and reproducible knockout phenotypes, ensuring reliable experimental outcomes.

These unique features enhance the potential of the HES7 Gene Knockout Cell Lines to meet the needs of researchers and clinicians alike, as they provide a more accurate representation of genetic manipulation and its effects.

With our extensive expertise in genetic engineering and a commitment to delivering high-quality biological products, we offer researchers the tools they need to explore the complexities of gene regulation with confidence and precision.

Please note that all services are for research use only. Not intended for any clinical use.

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