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HECW2 Knockout Cell Lines

Gene: HECW2

Official Full Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by HGNC

Gene Summary: This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20612 HECW2 Knockout cell line (HCT 116) Human HECW2 1:2~1:4 Negative Online Inquiry
KO20613 HECW2 Knockout cell line (HEK293) Human HECW2 1:3~1:6 Negative Online Inquiry
KO20614 HECW2 Knockout cell line (A549) Human HECW2 1:3~1:4 Negative Online Inquiry

Background

HECW2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the HECW2 gene, providing invaluable tools for studying gene function, cellular signaling pathways, and the biological processes influenced by this specific protein. This knockout technique utilizes advanced CRISPR-Cas9 technology, ensuring precision in gene editing, which allows researchers to investigate the phenotypic changes and molecular mechanisms that arise from the absence of HECW2.

The primary function of HECW2 in cells includes facilitating various aspects of cellular homeostasis and modulating immune responses. By employing these knockout cell lines, researchers can elucidate the roles of HECW2 in physiological and pathological conditions, such as cancer, neurodegeneration, and immune disorders. This detailed understanding can pave the way for the development of targeted therapies and enhance our comprehension of complex biological systems.

One of the significant advantages of HECW2 Gene Knockout Cell Lines is their specificity and reliability compared to alternative models, such as siRNA or shRNA knockdowns, which can result in off-target effects and incomplete gene silencing. The creation of stable knockout cell lines ensures a reproducible and consistent experimental model, allowing for more robust data collection and analysis.

For researchers and clinicians, these cell lines are vital for validating hypotheses, screening potential therapeutic agents, and accelerating the discovery of novel treatments. Utilizing HECW2 knockout models facilitates the translation of basic research into clinical applications, making them a crucial asset in both laboratory and translational medicine settings.

With a proven track record in gene editing and a commitment to advancing biomedical research, our company offers top-tier products like the HECW2 Gene Knockout Cell Lines, helping scientists push the boundaries of discovery and innovation in genetics and cellular biology. Our expertise ensures that you receive high-quality, well-characterized cell lines that meet the rigorous demands of contemporary research.

Please note that all services are for research use only. Not intended for any clinical use.

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