Gene: HEBP2
Official Full Name: heme binding protein 2provided by HGNC
Gene Summary: The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29069 | HEBP2 Knockout cell line (HeLa) | Human | HEBP2 | 1:3~1:6 | Negative | Online Inquiry |
KO29070 | HEBP2 Knockout cell line (HCT 116) | Human | HEBP2 | 1:2~1:4 | Negative | Online Inquiry |
KO29071 | HEBP2 Knockout cell line (HEK293) | Human | HEBP2 | 1:3~1:6 | Negative | Online Inquiry |
KO29072 | HEBP2 Knockout cell line (A549) | Human | HEBP2 | 1:3~1:4 | Negative | Online Inquiry |
HEBP2 Gene Knockout Cell Lines are genetically modified cellular models specifically designed for research purposes that employ a targeted gene disruption approach to silence the HEBP2 gene. HEBP2, or Hemoglobin Epsilon-Globin Binding Protein 2, plays a critical role in cellular processes related to erythropoiesis and hemoglobin metabolism. By creating knockout cell lines, researchers can investigate the gene's function, elucidate its role in various physiological and pathological conditions, and explore novel therapeutic approaches.
These cell lines operate by utilizing CRISPR/Cas9 technology for precise gene editing, effectively abrogating the expression of the HEBP2 gene. This disruption allows for the study of downstream effects and compensatory mechanisms in cellular pathways, providing insights into the gene's biological significance. Importantly, they facilitate research into blood disorders such as anemia and thalassemia, where the function of hemoglobin is critically impaired.
The scientific importance of HEBP2 Gene Knockout Cell Lines is substantial, providing a powerful tool for both basic and translational research settings. Their ability to mimic human disease states in vitro enables more accurate testing of pharmacological compounds, which is crucial for drug discovery and development efforts. Moreover, using these cell lines can substantially reduce the reliance on animal models, aligning with ethical research practices while streamlining timelines.
What sets our HEBP2 Gene Knockout Cell Lines apart from traditional models is their high specificity and reproducibility, ensuring that results are both reliable and easily interpretable. The seamless integration of gene editing technologies into their creation guarantees the elimination of off-target effects, a common concern in genetic studies. Consequently, these cell lines stand as a premier choice for researchers aiming to decode the roles of HEBP2 in health and disease.
Investing in HEBP2 Gene Knockout Cell Lines offers an invaluable advantage, as they not only expedite the research process but also enhance the validity of experimental outcomes. They embody our commitment to providing high-quality biological products that empower scientists in their pursuit of groundbreaking discoveries. At [Your Company Name], we pride ourselves on our expertise in genetic engineering and our dedication to advancing biomedical research through innovative solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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