Gene: HDAC9
Official Full Name: histone deacetylase 9provided by HGNC
Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03897 | HDAC9 Knockout cell line (HCT 116) | Human | HDAC9 | 1:2~1:4 | Negative | Online Inquiry |
KO03898 | HDAC9 Knockout cell line (HEK293) | Human | HDAC9 | 1:3~1:6 | Negative | Online Inquiry |
HDAC9 Gene Knockout Cell Lines represent a breakthrough tool in molecular biology, designed to study the intricate roles of Histone Deacetylase 9 (HDAC9) in various cellular processes. These specially engineered cell lines are created through precise gene editing techniques that completely disrupt the HDAC9 gene, allowing researchers to analyze the effects of its absence on gene expression, cellular growth, differentiation, and more.
The key mechanism underlying the functionality of HDAC9 gene knockout cell lines lies in the disruption of epigenetic regulation mediated by histone deacetylases. By knocking out the HDAC9 gene, these cell lines allow for the accumulation of acetylated histones, leading to altered transcriptional profiles and influencing pathways critical for cancer, immune response, and neurodegenerative diseases. Such cellular models are invaluable for the investigation of the molecular mechanisms behind these conditions and for the testing of novel therapeutics targeting HDACs.
Scientifically, HDAC9 gene knockout cell lines serve pivotal roles in both research and clinical applications, providing insights into the gene's contributions to pathophysiological states. They are indispensable for drug discovery efforts, allowing for high-throughput screening of compounds that can modulate HDAC activity. The unique capability to delineate specific functions of HDAC9 sets this product apart from other available cell lines that may not offer such targeted insights.
Compared to conventional cell lines, these knockout models enable a more nuanced understanding of gene function without the confounding effects of gene dosage. This specificity enhances the quality of data obtained from experimental pathways, ensuring that results are directly attributable to the absence of HDAC9.
For researchers and clinicians devoted to unraveling complex biological systems and developing targeted therapies, HDAC9 Gene Knockout Cell Lines provide unmatched value. With a dedicated team of scientists and state-of-the-art facilities, our company is at the forefront of biological product development, committed to providing innovative solutions that empower research and therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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