Gene: HDAC10
Official Full Name: histone deacetylase 10provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00428 | HDAC10 knockout cell line (HEK293) | Human | HDAC10 | 1:3~1:6 | Negative | Online Inquiry |
KO25310 | HDAC10 Knockout cell line (HeLa) | Human | HDAC10 | 1:3~1:6 | Negative | Online Inquiry |
KO25311 | HDAC10 Knockout cell line (HCT 116) | Human | HDAC10 | 1:2~1:4 | Negative | Online Inquiry |
KO25312 | HDAC10 Knockout cell line (A549) | Human | HDAC10 | 1:3~1:4 | Negative | Online Inquiry |
HDAC10 Gene Knockout Cell Lines are genetically modified cells in which the HDAC10 gene has been specifically disrupted, enabling researchers to study the functional consequences of this histone deacetylase enzyme in a controlled environment. HDAC10 is known to play a significant role in epigenetic regulation, particularly in the modification of histone proteins, which influences chromatin architecture and gene expression. By eliminating the activity of HDAC10, these knockout cell lines allow for the interrogation of pathways affected by changes in histone acetylation, ultimately contributing to our understanding of various biological processes, including cell proliferation, differentiation, and apoptosis.
The primary function of HDAC10 involves the removal of acetyl groups from histones, leading to a closed chromatin configuration that suppresses gene expression. In these knockout cell lines, researchers can observe shifts in transcriptional activity, elucidating the intricate relationships between histone modifications, chromatin structure, and genomic stability. Such insights are invaluable for investigating diseases associated with dysregulated epigenetic mechanisms, including cancer, neurodegenerative disorders, and cardiovascular diseases.
The scientific importance of HDAC10 Gene Knockout Cell Lines is underscored by their broad applications in research and potential clinical settings. They serve as powerful tools for gene therapy studies, drug discovery, and the assessment of novel therapeutic agents targeting HDACs. Additionally, these lines can facilitate high-throughput screening of compounds that may reverse the pathological effects of HDAC dysregulation.
Compared to other commonly used gene knockout models, our HDAC10 cell lines offer unique advantages, including enhanced specificity and reproducibility in experiments, which is crucial for achieving reliable results. Furthermore, these cell lines are supported by comprehensive characterization data, affording users confidence in their experimental outcomes.
For researchers and clinicians aiming to explore the complexities of epigenetic regulation and its implications for health and disease, HDAC10 Gene Knockout Cell Lines provide a critical resource. Our company prides itself on its dedication to advancing biological research through high-quality, precisely engineered cell lines, backed by a team of experts with extensive experience in genetic engineering and cellular biology. By choosing our product, you are equipping yourself with a potent tool for unlocking the mysteries of gene regulation and discovering novel therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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