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HCK Knockout Cell Lines

Gene: HCK

Official Full Name: HCK proto-oncogene, Src family tyrosine kinaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00499 HCK Knockout cell line (HEK293) Human HCK 1:3~1:6 Negative Online Inquiry

Background

HCK Gene Knockout Cell Lines represent a pivotal biotechnological advancement used in molecular biology and genetic research. These cell lines are specifically engineered to have deletions in the HCK (Hematopoietic Cell Kinase) gene, which is known to play a crucial role in various cellular processes, including hematopoiesis, immune response, and signaling pathways. By employing CRISPR/Cas9 technology or similar genome-editing techniques, these cell lines facilitate the study of HCK's functional implications within the larger choreography of cell signaling.

The primary function of HCK Gene Knockout Cell Lines lies in their ability to help researchers elucidate the role of the HCK gene in various biological processes. The lack of HCK expression enables scientists to analyze the resulting phenotypic changes and infer the gene's participation in immune responses, cancer progression, and cellular motility. This specificity allows for targeted research applications, including drug discovery efforts focused on hematological malignancies or immune system disorders.

The scientific importance of these knockout cell lines is underscored by their applications in both basic and translational research settings. In academic laboratories, they serve as invaluable tools for investigating gene function, while clinical researchers can utilize them to model diseases and screen therapeutic compounds for efficacy against HCK-related pathologies. This dual utility enriches the understanding of complex biological systems, ultimately fostering advancements in patient care.

Distinct advantages of our HCK Gene Knockout Cell Lines over alternatives include their high specificity, reproducibility, and comprehensive characterization. Unlike other knockouts that may induce off-target effects, our lines are meticulously validated to ensure they accurately reflect the genetic dependencies linked to the HCK gene, yielding reliable and interpretable data for scientific investigation.

For researchers and clinicians, the value of the HCK Gene Knockout Cell Lines is in their potential to unlock new avenues of discovery, accelerate drug development processes, and provide insights into therapeutic interventions. Additionally, our commitment to quality ensures that users receive products backed by rigorous validation and support.

With years of expertise in producing high-quality biological products, our company is dedicated to empowering the scientific community with innovative tools that drive progress in research and healthcare. Our HCK Gene Knockout Cell Lines exemplify this mission by providing researchers with the resources necessary to advance their work in genetics and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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