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H4C1 Knockout Cell Lines

Gene: H4C1

Official Full Name: H4 clustered histone 1provided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34225 H4C1 Knockout cell line (HeLa) Human H4C1 1:3~1:6 Negative Online Inquiry
KO34226 H4C1 Knockout cell line (HEK293) Human H4C1 1:3~1:6 Negative Online Inquiry

Background

H4C1 Gene Knockout Cell Lines are a cutting-edge biological tool designed to facilitate the exploration of gene function and regulation through targeted gene disruption. This innovative product consists of cell lines engineered to possess specific gene knockouts, enabling researchers to study the influence of those genes on cellular behavior, signaling pathways, and disease mechanisms. The underlying technology typically employs the CRISPR-Cas9 system, allowing for precise editing of genomic DNA to create knockout mutations that render target genes inactive.

The key function of H4C1 Gene Knockout Cell Lines lies in their ability to serve as a controlled environment for dissecting gene activity and its physiological consequences. By analyzing the phenotypic changes and cellular responses following gene knockout, researchers can discern the roles of specific genes in various biological processes, paving the way for advancements in molecular biology, genetics, cancer research, and therapeutics. These cell lines are essential for elucidating the pathophysiology of diseases and for developing new pharmacological strategies.

The scientific importance of these knockout cell lines extends into both research and clinical applications. They provide a powerful framework for drug screening, biomarker discovery, and validating gene-targeted therapies. Unlike traditional methods of gene disruption, H4C1 Gene Knockout Cell Lines allow for more reproducible and reliable results, significantly streamlining experimental protocols.

One of the standout advantages of H4C1 Gene Knockout Cell Lines is their specificity and ease of use. Compared to other gene-editing methods that may involve labor-intensive protocols or lack precision, these knockout lines offer a faster turnaround time and robust performance in a variety of assays. Additionally, they come with comprehensive supporting documentation to aid in experimental design and implementation.

For researchers and clinicians looking to unlock the complexities of gene function and disease, H4C1 Gene Knockout Cell Lines represent a valuable asset in the toolbox of modern molecular biology. The contributions of our company, with extensive expertise in gene editing technologies and cell line development, provide a strong foundation for delivering high-quality products that meet the demands of scientific inquiry. Our commitment to innovation ensures that you have access to the most advanced research tools available, empowering your discoveries in genetics and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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