Gene: H3C2
Official Full Name: H3 clustered histone 2provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34233 | H3C2 Knockout cell line (HeLa) | Human | H3C2 | 1:3~1:6 | Negative | Online Inquiry |
KO34234 | H3C2 Knockout cell line (HCT 116) | Human | H3C2 | 1:2~1:4 | Negative | Online Inquiry |
KO34235 | H3C2 Knockout cell line (HEK293) | Human | H3C2 | 1:3~1:6 | Negative | Online Inquiry |
KO34236 | H3C2 Knockout cell line (A549) | Human | H3C2 | 1:3~1:4 | Negative | Online Inquiry |
H3C2 gene knockout cell lines are genetically modified cells specifically designed to lack the H3C2 gene, which has been implicated in various biological processes and diseases. These cell lines serve as invaluable tools for molecular and cellular biology research, allowing scientists to study the functional roles of the H3C2 gene in phenotypic outcomes such as cellular signaling, differentiation, and response to therapeutics. Through the application of CRISPR/Cas9 gene editing technologies, these knockout lines have been meticulously engineered to provide a reproducible and reliable model for studying gene function and regulation.
The primary mechanism of action involves the precise deletion of the H3C2 gene, enabling researchers to examine the downstream effects of its absence. This feature allows for the investigation of pathways that may be disrupted in pathological conditions or during drug development processes. The H3C2 knockout cell lines are integral for understanding gene interactions and the molecular basis of diseases, thereby facilitating advancements in targeted therapies and precision medicine.
In research and clinical settings, these cell lines hold significant scientific importance. They can be employed in assays for drug screening, gene expression analysis, and the development of therapeutic strategies aimed at diseases associated with H3C2 dysregulation. Unlike traditional cell lines, our H3C2 knockout models provide a more relevant biological context, as they closely mimic the disease state by removing the specific gene in question.
One notable advantage of the H3C2 gene knockout cell lines is their high reproducibility and ease of use, which significantly reduces the variability often present in experimental outcomes. Additionally, these cell lines are further validated against existing biological data, which enhances their reliability and applicability in research.
For researchers, clinicians, and pharmaceutical companies aiming to uncover new insights into gene function and explore innovative treatment options, our H3C2 gene knockout cell lines represent a cutting-edge resource. Leveraging our deep expertise in gene-editing technologies, our company is committed to providing high-quality biological products that meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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