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H2BC26 Knockout Cell Lines

Gene: H2BC26

Official Full Name: H2B clustered histone 26provided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17194 H2BC26 Knockout cell line (HeLa) Human H2BC26 1:3~1:6 Negative Online Inquiry
KO17195 H2BC26 Knockout cell line (HCT 116) Human H2BC26 1:2~1:4 Negative Online Inquiry
KO17196 H2BC26 Knockout cell line (HEK293) Human H2BC26 1:3~1:6 Negative Online Inquiry
KO17197 H2BC26 Knockout cell line (A549) Human H2BC26 1:3~1:4 Negative Online Inquiry

Background

H2BC26 Gene Knockout Cell Lines are specialized cell models that have undergone targeted gene editing to inactivate the H2BC26 gene, enabling researchers to investigate the biological consequences of gene loss. These cell lines employ advanced CRISPR-Cas9 technology, which utilizes a guide RNA to specifically direct the Cas9 endonuclease to create double-strand breaks in the genomic DNA at the H2BC26 locus. The subsequent DNA repair processes, primarily non-homologous end joining, lead to the introduction of insertion or deletion mutations, effectively knocking out the gene function.

The key function of H2BC26 Gene Knockout Cell Lines lies in their ability to serve as powerful tools in functional genomics, cell biology, and cancer research. By studying the effects of H2BC26 disruption, researchers can elucidate its role in cellular processes such as proliferation, differentiation, and apoptosis. This understanding is crucial for the development of targeted therapies and more personalized approaches in clinical settings, particularly in the context of diseases where the H2BC26 gene is implicated.

What sets H2BC26 Gene Knockout Cell Lines apart from traditional models is their precise gene editing, which minimizes off-target activities and maximizes the reliability of experimental outcomes. Unlike conventional knockout methodologies, these cell lines provide a level of specificity that is unmatched, reducing the time and resources necessary for validating results.

For researchers and clinicians, the value of these cell lines is evident in their potential to accelerate discoveries and optimize experimental designs, particularly in understanding gene-function relationships and the underlying mechanisms of disease. The use of H2BC26 knockouts facilitates the identification of novel therapeutic targets, supporting advancements in precision medicine.

Our company specializes in the development of high-quality research reagents and cell models, and we pride ourselves on delivering reliable products backed by rigorous scientific validation and expert support. By choosing H2BC26 Gene Knockout Cell Lines, you are investing in a resource that embodies innovation and excellence in the life sciences field.

Please note that all services are for research use only. Not intended for any clinical use.

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