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H2BC12 Knockout Cell Lines

Gene: H2BC12

Official Full Name: H2B clustered histone 12provided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24311 H2BC12 Knockout cell line (HeLa) Human H2BC12 1:3~1:6 Negative Online Inquiry
KO24312 H2BC12 Knockout cell line (HCT 116) Human H2BC12 1:2~1:4 Negative Online Inquiry
KO24313 H2BC12 Knockout cell line (HEK293) Human H2BC12 1:3~1:6 Negative Online Inquiry
KO24314 H2BC12 Knockout cell line (A549) Human H2BC12 1:3~1:4 Negative Online Inquiry

Background

H2BC12 Gene Knockout Cell Lines represent a crucial advancement in genetic research and therapeutic development, consisting of cell lines where the H2BC12 gene has been precisely disrupted through CRISPR-Cas9 gene editing technology. These knockout cell lines enable researchers to investigate the functional role of H2BC12 in cellular processes, such as cell proliferation, differentiation, and response to environmental stressors.

The mechanism behind these knockout cell lines involves the targeted deletion of specific DNA sequences within the H2BC12 gene, effectively silencing its expression and allowing for the analysis of subsequent phenotypic changes. By studying these alterations, researchers can elucidate the gene’s impact on various biological pathways, leading to enhanced understanding of its potential role in diseases, including cancer and genetic disorders.

The scientific importance of H2BC12 Gene Knockout Cell Lines is profound, particularly in the context of drug discovery and development. They provide a reliable system for high-throughput screening of potential therapeutic agents, enabling the identification of compounds that can restore or compensate for the functional loss of H2BC12. Additionally, these cell lines can be invaluable tools in academic and clinical laboratories that focus on gene function, cellular signaling pathways, and the development of novel treatment strategies.

One of the unique selling points of our H2BC12 Gene Knockout Cell Lines is their rigorously validated lineage, which ensures reproducibility and reliability across experiments. Compared to alternative methods for gene knockout, such as traditional homologous recombination, CRISPR-Cas9 offers a more efficient, rapid, and cost-effective approach, making it easier for laboratories to implement these essential tools into their research pipelines.

For researchers and clinicians, the value of H2BC12 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking discoveries that could lead to the development of innovative therapies. By providing a reliable model system, these cell lines empower scientists to accelerate their research and contribute to the understanding of complex genetic interactions.

At our company, we are committed to advancing biological research through high-quality genetic tools. With years of expertise in developing specialized cell line models, we pride ourselves on delivering products that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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