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H1-0 Knockout Cell Lines

Gene: H1-0

Official Full Name: H1.0 linker histoneprovided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37443 H1-0 Knockout cell line (HeLa) Human H1-0 1:3~1:6 Negative Online Inquiry
KO37444 H1-0 Knockout cell line (HCT 116) Human H1-0 1:2~1:4 Negative Online Inquiry
KO37445 H1-0 Knockout cell line (HEK293) Human H1-0 1:3~1:6 Negative Online Inquiry
KO37446 H1-0 Knockout cell line (A549) Human H1-0 1:3~1:4 Negative Online Inquiry

Background

H1-0 Gene Knockout Cell Lines are specifically engineered mammalian cell lines where the H1 gene is inactivated through targeted genome editing techniques, such as CRISPR/Cas9. This innovative approach allows for the robust study of gene function, regulation, and the phenotypic consequences of gene loss, making H1-0 cell lines a valuable tool in molecular biology. By utilizing these knockout models, researchers can explore the specific roles of the H1 gene in various biological processes, including cell proliferation, apoptosis, differentiation, and disease pathology.

The functioning of H1-0 Gene Knockout Cell Lines is grounded in the disruption of the H1 gene loci, which is integral to chromatin structure and stabilization. This disruption leads to altered gene expression profiles and downstream signaling pathways, offering insights into the gene's contributions to cellular homeostasis and its potential implications in diseases like cancer. By studying these cell lines, researchers can unveil critical mechanisms underlying various pathophysiological conditions, thus aiding in the identification of therapeutic targets.

The scientific importance of H1-0 gene knockout cell lines extends beyond basic research; they hold significant potential in drug development and testing. In clinical settings, utilizing these cell lines can facilitate the assessment of drug responses, toxicity, and efficacy in models that closely mimic human pathologies.

Compared to alternative knockout systems, H1-0 cell lines benefit from improved targeted integration, creating stable and reproducible models. These cells also exhibit enhanced genetic fidelity and cellular behavior, rendering them a trusted choice for researchers aiming for high-quality experimental results.

In sum, H1-0 Gene Knockout Cell Lines provide researchers and clinicians with a powerful and efficient tool to dissect gene function and its implications for health and disease. Our company prides itself on its extensive expertise in developing high-quality biological products, ensuring customers receive reliable and accurate models for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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