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GTSE1 Knockout Cell Lines

Gene: GTSE1

Official Full Name: G2 and S-phase expressed 1provided by HGNC

Gene Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06366 GTSE1 Knockout cell line (HeLa) Human GTSE1 1:3~1:6 Negative Online Inquiry
KO06367 GTSE1 Knockout cell line (HCT 116) Human GTSE1 1:2~1:4 Negative Online Inquiry
KO06368 GTSE1 Knockout cell line (HEK293) Human GTSE1 1:3~1:6 Negative Online Inquiry
KO06369 GTSE1 Knockout cell line (A549) Human GTSE1 1:3~1:4 Negative Online Inquiry

Background

GTSE1 Gene Knockout Cell Lines represent a pivotal tool in genomic research and cellular biology, specifically designed to elucidate the function of the GTSE1 gene, which is implicated in various cellular processes including the cell cycle, DNA repair, and oncogenic pathways. These cell lines are generated using advanced CRISPR-Cas9 technology, allowing precise deletion of the GTSE1 gene, thereby creating a model to study its biological roles in a controlled environment.

The primary mechanism of action for the GTSE1 Gene Knockout Cell Lines revolves around the disruption of the GTSE1 gene, facilitating researchers to observe downstream effects on cell proliferation, stress response, and apoptosis. By employing these knockout cell lines, scientists can investigate the contribution of GTSE1 in tumorigenesis, providing insights into potential therapeutic targets.

In terms of scientific importance, these cell lines serve as invaluable resources in both basic and applied research settings. Their applications span cancer biology, drug development, and the study of genetic disorders, making them critical for advancing our understanding of disease mechanisms. The ability to knock out GTSE1 allows researchers to delineate its role in cellular function and its potential interplay with various pharmacological interventions.

Compared to conventional gene silencing methods such as RNA interference, GTSE1 Gene Knockout Cell Lines offer several advantages. Permanent gene modification allows for the prolonged study of gene function without the transient effects associated with non-integrative techniques. This stability enhances experimental reproducibility and reliability of data.

Researchers and clinicians will find significant value in these knockout models, as they provide a robust platform for investigating disease pathways and testing novel therapeutic approaches. The insights gleaned from experiments using these cell lines can guide the development of targeted therapies, ultimately leading to enhanced clinical outcomes.

Our company, with its extensive expertise in genomic engineering and a commitment to providing cutting-edge biological tools, prides itself on delivering high-quality products like the GTSE1 Gene Knockout Cell Lines. We are dedicated to empowering the scientific community with innovative solutions that drive research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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