Gene: GTF3C6
Official Full Name: general transcription factor IIIC subunit 6provided by HGNC
Gene Summary: RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30938 | GTF3C6 Knockout cell line (HeLa) | Human | GTF3C6 | 1:3~1:6 | Negative | Online Inquiry |
KO30939 | GTF3C6 Knockout cell line (HCT 116) | Human | GTF3C6 | 1:2~1:4 | Negative | Online Inquiry |
KO30940 | GTF3C6 Knockout cell line (HEK293) | Human | GTF3C6 | 1:3~1:6 | Negative | Online Inquiry |
KO30941 | GTF3C6 Knockout cell line (A549) | Human | GTF3C6 | 1:3~1:4 | Negative | Online Inquiry |
GTF3C6 Gene Knockout Cell Lines are engineered human cell lines that have had the GTF3C6 gene disrupted through precise CRISPR-Cas9 gene editing techniques. The GTF3C6 gene is a critical component of the transcription initiation complex, playing a key role in RNA polymerase III-mediated transcription. By creating knockout models, researchers can uncover the functional implications of GTF3C6 loss, revealing insights into cellular processes such as gene regulation, cell cycle progression, and overall cellular health.
The mechanism behind the action of GTF3C6 knockouts stems from the inability of cells to express the GTF3C6 protein, which leads to altered transcriptional regulation. This malfunction can result in modifications of the cellular transcriptome, enabling researchers to study disease mechanisms, evaluate drug responses, and assess the roles of GTF3C6 in various biological pathways. Such cellular models can significantly advance our understanding of genetic disorders linked to transcriptional dysregulation, including certain cancers and neurodevelopmental diseases.
The scientific importance of GTF3C6 Gene Knockout Cell Lines lies in their potential application across diverse research fields, including molecular biology, genetics, and cancer research. They provide invaluable tools for studying the effects of GTF3C6 deficiency in a controlled environment and allow for the development and testing of therapeutic interventions.
What sets GTF3C6 Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility, ensuring consistent results that are essential for reliable research outcomes. Additionally, these cell lines can be easily cultured and integrated into various experimental setups, making them user-friendly for researchers tackling complex biological questions.
The value of GTF3C6 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated. They represent a critical resource for understanding gene function, exploring disease mechanisms, and ultimately guiding the development of novel therapeutic strategies. By providing tools that facilitate groundbreaking research, our company is committed to advancing scientific discovery and improving human health. With extensive expertise in genetic engineering and cellular biology, we strive to equip researchers with the resources necessary to unlock new frontiers in molecular research.
Please note that all services are for research use only. Not intended for any clinical use.
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