Gene: GSAP
Official Full Name: gamma-secretase activating proteinprovided by HGNC
Gene Summary: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21840 | GSAP Knockout cell line (HEK293) | Human | GSAP | 1:3~1:6 | Negative | Online Inquiry |
KO21841 | GSAP Knockout cell line (A549) | Human | GSAP | 1:3~1:4 | Negative | Online Inquiry |
GSAP Gene Knockout Cell Lines are specialized cellular models engineered for the precise disruption of the GSAP gene, which encodes the enzyme involved in the production of bioactive lipids crucial for cellular signaling and metabolism. By employing CRISPR-Cas9 technology, these cell lines enable researchers to achieve targeted gene knockout, facilitating a deeper understanding of the gene's functional role in various biological processes, including apoptosis, inflammation, and neurodegeneration.
The key mechanism behind GSAP Gene Knockout Cell Lines involves the introduction of double-strand breaks at specific loci within the GSAP gene, leading to insertions or deletions (indels) that render the gene nonfunctional. The resulting cellular phenotypes can be analyzed for changes in lipid metabolism, cell signaling pathways, and overall cellular behavior. This allows scientists to unravel complex disease mechanisms and identify potential therapeutic targets.
In the realm of research and clinical applications, GSAP Gene Knockout Cell Lines serve as vital tools for studying diseases associated with dysregulated lipid metabolism, such as Alzheimer's disease and other neurodegenerative disorders. They provide a platform for high-throughput drug screening and biomarker discovery, ultimately guiding the development of novel therapies.
A significant advantage of our GSAP Gene Knockout Cell Lines is their high specificity and efficiency compared to traditional knockout methods, which often yield off-target effects. Additionally, the readiness of these cell lines for immediate application reduces the time and resources required for genotyping and confirmation, making them suitable for both academic and industrial research settings.
Researchers and clinicians can greatly benefit from the precision and insights provided by GSAP Gene Knockout Cell Lines, leading to advancements in tailored therapeutic approaches and innovative treatment strategies. Our expertise in genetic engineering and commitment to providing high-quality biological products ensure that our offerings meet the stringent demands of modern biomedical research, ultimately accelerating discoveries that could lead to breakthroughs in understanding complex diseases.
Please note that all services are for research use only. Not intended for any clinical use.
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