Gene: GREB1
Official Full Name: growth regulating estrogen receptor binding 1provided by HGNC
Gene Summary: This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32920 | GREB1 Knockout cell line (HCT 116) | Human | GREB1 | 1:2~1:4 | Negative | Online Inquiry |
KO32921 | GREB1 Knockout cell line (HEK293) | Human | GREB1 | 1:3~1:6 | Negative | Online Inquiry |
KO32922 | GREB1 Knockout cell line (A549) | Human | GREB1 | 1:3~1:4 | Negative | Online Inquiry |
GREB1 Gene Knockout Cell Lines are sophisticated biological tools designed for functional genomics research, enabling an in-depth understanding of the roles played by the GREB1 gene in various biological processes. These genetically modified cell lines are engineered to have a complete deletion of the GREB1 gene, which encodes a protein implicated in hormone signaling and cancer progression. By utilizing CRISPR-Cas9 genome editing technology, these cell lines allow researchers to investigate the functional consequences of GREB1 deficiency on cellular behavior, gene expression, and signaling pathways.
The primary function of GREB1 Gene Knockout Cell Lines lies in their ability to facilitate the study of GREB1-associated phenotypes, such as changes in cell proliferation, migration, and response to hormonal stimuli. Researchers can utilize these cell lines to assess the impact of GREB1 knockout on the steroid hormone signaling axis, thereby elucidating its role in conditions like breast cancer and endometrial carcinoma. The mechanistic insights garnered from such studies can lead to the identification of novel therapeutic targets, fostering advancements in personalized medicine.
In terms of scientific significance, these knockout cell lines are invaluable in both research and clinical settings. They provide a robust platform for pharmacological testing and the preclinical evaluation of potential therapeutic agents aimed at modulating GREB1 expression or function. When compared to conventional cell lines, GREB1 Gene Knockout Cell Lines offer a more physiologically relevant model, exhibiting closer alignment with in vivo systems and thereby enhancing the translational potential of research findings.
The unique selling points of these cell lines include their high specificity and reproducibility, guaranteed through rigorous validation processes, ensuring that researchers can achieve consistent results. Furthermore, these cell lines are available in various genetic backgrounds, catering to the diverse needs of the scientific community and promoting collaboration across disciplines.
For researchers, clinicians, and biotechnology professionals, GREB1 Gene Knockout Cell Lines represent a powerful asset in the quest to unravel the complexities of gene function and its implications in disease. By leveraging these advanced tools, users can make informed decisions and contribute significantly to the understanding of gene regulation and its impact on health.
Our company brings years of expertise in the production and quality assurance of biological model systems, ensuring that our GREB1 Gene Knockout Cell Lines meet the highest standards of scientific rigor and reliability. This commitment to excellence enables better research outcomes and fosters innovation in targeted therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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