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GRB14 Knockout Cell Lines

Gene: GRB14

Official Full Name: growth factor receptor bound protein 14provided by HGNC

Gene Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37506 GRB14 Knockout cell line (HeLa) Human GRB14 1:3~1:6 Negative Online Inquiry
KO37507 GRB14 Knockout cell line (HCT 116) Human GRB14 1:2~1:4 Negative Online Inquiry
KO37508 GRB14 Knockout cell line (HEK293) Human GRB14 1:3~1:6 Negative Online Inquiry
KO37509 GRB14 Knockout cell line (A549) Human GRB14 1:3~1:4 Negative Online Inquiry

Background

GRB14 Gene Knockout Cell Lines are genetically engineered cell lines in which the GRB14 gene has been selectively inactivated. GRB14 is known for its role in mediating insulin signaling and modulating cellular responses to growth factors. These knockout models allow researchers to study the functional consequences of GRB14 absence, investigating its impact on proliferative and metabolic pathways within various cellular contexts.

The key function of GRB14 in cellular biology lies in its interaction with receptor tyrosine kinases and intracellular signaling pathways. By inhibiting the actions of insulin and other growth factors, GRB14 acts as a critical regulatory component. When researchers use GRB14 Gene Knockout Cell Lines, they can elucidate the mechanistic roles of GRB14 in metabolic diseases, particularly in understanding insulin resistance and triggering the signaling cascades involved in cellular growth and differentiation.

In both research and clinical settings, these cell lines are invaluable for unveiling the implications of GRB14 gene regulation and its interactions in pathophysiology. They serve as essential tools for drug discovery and development, allowing for the screening of therapeutic compounds that may restore normal function in dysregulated signaling pathways. Furthermore, the insights derived from these models have significant potential in metabolic syndrome, obesity, and diabetes research.

Compared to alternative cell models, GRB14 Gene Knockout Cell Lines offer distinct advantages, including precise gene editing achieved through CRISPR-Cas9 technology that ensures complete gene knockout, resulting in reproducible and consistent experimental outcomes. This high specificity minimizes off-target effects, thereby enhancing the reliability of experimental data and conclusions drawn from these studies.

Researchers and clinicians seeking to advance their understanding of metabolic signaling pathways and therapeutic interventions will find these cell lines indispensable. By harnessing the GRB14 Gene Knockout Cell Lines, users can accelerate their research outcomes and translate findings into impactful therapeutic strategies.

Our company prides itself on delivering cutting-edge biological products backed by rigorous scientific expertise. We focus on developing innovative research tools like the GRB14 Gene Knockout Cell Lines to empower researchers in their quest for breakthroughs in cellular biology and disease therapeutics.

Please note that all services are for research use only. Not intended for any clinical use.

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