Gene: GRAMD2A
Official Full Name: GRAM domain containing 2Aprovided by HGNC
Gene Summary: Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21428 | GRAMD2A Knockout cell line (HCT 116) | Human | GRAMD2A | 1:2~1:4 | Negative | Online Inquiry |
GRAMD2A Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the comprehensive study of the GRAMD2A gene and its functional implications in various biological processes. These knockout cell lines are created through precise genetic modifications that render the GRAMD2A protein non-functional, thereby providing researchers with a valuable tool for investigating the role of this gene in cellular mechanisms and disease pathways.
The primary function of the GRAMD2A knockout model is to elucidate the gene’s involvement in lipid metabolism and cell signaling pathways, particularly those associated with endoplasmic reticulum stress responses. By employing CRISPR-Cas9 or similar genome-editing technologies, these cell lines enable scientists to assess phenotypic changes, signaling alterations, and cellular stress responses that result from the absence of GRAMD2A. This approach allows for a deeper understanding of how GRAMD2A contributes to physiological homeostasis and its potential role in diseases such as metabolic disorders and cancer.
From a scientific perspective, GRAMD2A Gene Knockout Cell Lines are instrumental in both basic and applied research. They provide invaluable insights into gene function, enabling researchers to explore drug mechanisms, screen for therapeutic targets, and study genetic interactions that may lead to novel treatment strategies. Furthermore, these cell lines are crucial for conducting high-throughput assays and validating hypotheses concerning GRAMD2A-related pathways in real-time cellular contexts.
In comparison to other genetic models, our GRAMD2A knockout cell lines are specifically validated for consistent knockout efficiency, minimal off-target effects, and reproducibility in various experimental conditions. This high level of precision ensures that researchers can obtain reliable data, accelerating their research timelines and enhancing the quality of their findings.
Researchers and clinicians seeking to advance their studies will find GRAMD2A Gene Knockout Cell Lines to be an indispensable addition to their experimental repertoire. These cell lines not only broaden the scope of investigation into critical biological phenomena but also open up avenues for therapeutic innovation targeted at cardiovascular diseases, obesity, and other metabolic syndromes.
At [Your Company Name], we pride ourselves on our expertise in genetic engineering and provide high-quality biological products tailored to meet the specific needs of research institutions and clinical laboratories. Our commitment to scientific excellence and innovation ensures that our offerings empower researchers to push the boundaries of their work, ultimately leading to groundbreaking discoveries and advancements in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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