Gene: GPT2
Official Full Name: glutamic--pyruvic transaminase 2provided by HGNC
Gene Summary: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24700 | GPT2 Knockout cell line (HeLa) | Human | GPT2 | 1:3~1:6 | Negative | Online Inquiry |
KO24701 | GPT2 Knockout cell line (HCT 116) | Human | GPT2 | 1:2~1:4 | Negative | Online Inquiry |
KO24702 | GPT2 Knockout cell line (HEK293) | Human | GPT2 | 1:3~1:6 | Negative | Online Inquiry |
KO24703 | GPT2 Knockout cell line (A549) | Human | GPT2 | 1:3~1:4 | Negative | Online Inquiry |
GPT2 Gene Knockout Cell Lines are specifically engineered cellular models used to study the function of the GPT2 gene and its implications in various biological processes. These cell lines are created utilizing advanced CRISPR-Cas9 gene editing technology, which allows for precise modifications in the genome, specifically targeting the GPT2 gene to induce a loss of function. This knockout approach enables researchers to elucidate the role of GPT2 in metabolic pathways, signaling cascades, and disease mechanisms, particularly in the context of conditions such as cancer and metabolic disorders.
The primary mechanism through which these cell lines function involves the disruption of the GPT2 gene, leading to the loss of corresponding enzyme activity. This is crucial for understanding the gene's role in amino acid metabolism and its potential contributions to pathophysiological states. By employing GPT2 knockout models, researchers can design targeted experiments to investigate the effects of the absence of GPT2 on cellular behavior, enabling the identification of novel therapeutic targets and biomarkers.
The scientific importance of GPT2 Gene Knockout Cell Lines extends into both research and clinical settings. These cell lines serve as invaluable tools in drug discovery, functional genomics, and the study of genetic diseases. Their application can facilitate a deeper understanding of the biological relevance of gene targets, accelerate the development of personalized medicine approaches, and enhance the efficacy of therapeutic interventions.
What sets our GPT2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, ensuring consistent results that are reproducible across experimental settings. Moreover, these cell lines are rigorously validated to confirm the knockout efficiency, providing researchers with confidence in their experimental design.
For researchers and clinicians, the value of the GPT2 Gene Knockout Cell Lines lies not only in their ability to significantly advance our understanding of GPT2 biology but also in their potential to lead to innovative diagnostic and therapeutic strategies. Our company combines expertise in genetic engineering with a commitment to providing high-quality biological research products, ensuring that our clients have access to cutting-edge tools that support their pioneering work in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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