Gene: GPR87
Official Full Name: G protein-coupled receptor 87provided by HGNC
Gene Summary: This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21915 | GPR87 Knockout cell line (HCT 116) | Human | GPR87 | 1:2~1:4 | Negative | Online Inquiry |
GPR87 Gene Knockout Cell Lines are engineered human cell lines specifically modified to lack the GPR87 gene, a member of the G protein-coupled receptor family. These knockout cell lines serve as a critical tool for researchers investigating the physiological and pathological roles of GPR87 in various biological processes, including cell signaling, metabolism, and tumorigenesis. By eliminating the expression of GPR87, scientists can study the consequences of its absence, allowing them to elucidate its function and potential involvement in diseases such as cancer.
The key function of GPR87 knockout cell lines is to provide a controlled environment to assess cellular changes in the absence of GPR87. This technique enables the analysis of downstream signaling pathways, gene expression changes, and alterations in cellular behavior, such as proliferation, apoptosis, and migration. The knockout technology is based on CRISPR-Cas9 methodology, which allows for precise deletions, ensuring the comprehensive study of GPR87 interactions and its influence on cellular physiology.
The scientific importance of these cell lines lies in their applicability in both basic research and therapeutic development. Researchers can employ GPR87 knockout cell lines for drug screening, biomarker discovery, and the investigation of targeted therapies. In clinical settings, understanding the mechanisms of this receptor could lead to novel approaches in cancer treatment and other related pathologies.
Compared to alternative models, such as wild-type cell lines or non-invasive techniques that only infer GPR87 function, these knockout cell lines offer a definitive genetic approach with minimal background interference. This specificity grants researchers unparalleled insights, making their findings more reliable and valid.
Utilizing GPR87 Gene Knockout Cell Lines empowers researchers and clinicians to uncover the intricate roles and impacts of the GPR87 receptor in health and disease. Our commitment to providing cutting-edge biological tools is backed by years of expertise and innovation in genetic engineering, making our product a trusted and valuable asset for advancing scientific discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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