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GPR137B Knockout Cell Lines

Gene: GPR137B

Official Full Name: G protein-coupled receptor 137Bprovided by HGNC

Gene Summary: Involved in positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of autophagy. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00265 GPR137B Knockout cell line (HeLa) Human GPR137B 1:3~1:6 Negative Online Inquiry
KO34994 GPR137B Knockout cell line (HCT 116) Human GPR137B 1:2~1:4 Negative Online Inquiry
KO34995 GPR137B Knockout cell line (HEK293) Human GPR137B 1:3~1:6 Negative Online Inquiry
KO34996 GPR137B Knockout cell line (A549) Human GPR137B 1:3~1:4 Negative Online Inquiry

Background

GPR137B Gene Knockout Cell Lines are genetically modified cell lines in which the GPR137B gene has been completely disrupted or knocked out, providing a valuable tool for researchers investigating the physiological roles and molecular mechanisms of this G protein-coupled receptor (GPCR). These cell lines enable the specific evaluation of GPR137B-related signaling pathways and physiological processes, such as cellular proliferation, migration, and differentiation, thus facilitating a deeper understanding of the receptor's function in health and disease.

The key functions of GPR137B involve its role in modulating intracellular signaling cascades that may influence various cellular responses. By utilizing these knockout cell lines, researchers can observe the absence of GPR137B and its consequent effects on downstream signaling pathways, helping to elucidate its contributions to pathophysiological conditions, including cancer and metabolic disorders. The manipulation of these cell lines allows for the examination of how loss of GPR137B alters cellular behaviors, thereby paving the way for potential therapeutic strategies.

Scientifically significant, GPR137B Gene Knockout Cell Lines are crucial in both basic research and clinical applications. They can serve as models for drug discovery, helping to identify precise targets for therapeutic intervention and screening potential drug candidates. Furthermore, these cell lines can be instrumental in functional studies that aim to comprehend the receptor's role in various biological contexts.

What sets our GPR137B Gene Knockout Cell Lines apart from alternatives in the market is the precision and reliability of the knockout process, accompanied by thorough characterization and validation of the lines generated. This ensures that researchers are working with high-fidelity models that accurately reflect the loss of GPR137B function. Additionally, our commitment to quality and reproducibility provides users with the confidence that they are utilizing robust research tools.

For researchers and clinicians striving to unravel the complexity of GPCR signaling and its implications in human diseases, these cell lines represent an essential resource. They not only help streamline research endeavors but also foster innovation in developing targeted therapies. Our company prides itself on expertise in providing cutting-edge biological products, consistently meeting the evolving needs of scientific research and contributing to pioneering discoveries in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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