Home / GPHN Knockout Cell Lines

GPHN Knockout Cell Lines

Gene: GPHN

Official Full Name: gephyrinprovided by HGNC

Gene Summary: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32071 GPHN Knockout cell line (HeLa) Human GPHN 1:3~1:6 Negative Online Inquiry
KO32072 GPHN Knockout cell line (HCT 116) Human GPHN 1:2~1:4 Negative Online Inquiry
KO32073 GPHN Knockout cell line (HEK293) Human GPHN 1:3~1:6 Negative Online Inquiry
KO32074 GPHN Knockout cell line (A549) Human GPHN 1:3~1:4 Negative Online Inquiry

Background

GPHN Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate the study of the glyproline-histidine-aspartate-rich protein (GPHN), pivotal in numerous physiological processes. These cell lines have been created using precise gene-editing technologies, such as CRISPR-Cas9, to create a complete knockout of the GPHN gene, effectively allowing researchers to observe the resultant phenotypic changes and gain insight into the gene's function within cellular pathways.

The primary function of these cell lines is to enable functional studies of GPHN, thereby elucidating its role in cellular structure and signaling pathways. By providing a model system that lacks the GPHN protein, researchers can more easily investigate potential compensatory mechanisms, assess gene interactions, and evaluate the effects of pharmacological interventions. This functionality is invaluable for understanding disease mechanisms, particularly in conditions linked to abnormalities in protein function.

The scientific importance of GPHN Gene Knockout Cell Lines extends to multiple fields, including neuroscience, cancer biology, and metabolic disorders. In clinical research settings, these models serve as platforms for drug discovery and development, facilitating the identification of novel therapeutic targets. Moreover, understanding GPHN's role may lead to insights into developmental biology and the impact of genetic mutations on human health.

What sets GPHN Gene Knockout Cell Lines apart from traditional cell models is their specificity and reliability. Other knockout systems often have off-target effects or incomplete gene disruption, which can confound experimental results. Our cell lines, however, ensure a true knockout, providing researchers with confidence in their findings. Moreover, they are derived from well-characterized parental cell lines, ensuring compatibility with various assays and reducing the time needed for optimization.

For researchers, clinicians, and institutions, GPHN Gene Knockout Cell Lines represent an essential tool for advancing understanding of gene function and developing innovative therapies. With our extensive expertise in gene editing technologies and a commitment to quality, our company is dedicated to providing high-fidelity biological products that empower the scientific community to explore and elucidate complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.