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GPD2 Knockout Cell Lines

Gene: GPD2

Official Full Name: glycerol-3-phosphate dehydrogenase 2provided by HGNC

Gene Summary: The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37566 GPD2 Knockout cell line (HeLa) Human GPD2 1:3~1:6 Negative Online Inquiry
KO37567 GPD2 Knockout cell line (HCT 116) Human GPD2 1:2~1:4 Negative Online Inquiry
KO37568 GPD2 Knockout cell line (HEK293) Human GPD2 1:3~1:6 Negative Online Inquiry
KO37569 GPD2 Knockout cell line (A549) Human GPD2 1:3~1:4 Negative Online Inquiry

Background

GPD2 gene knockout cell lines are genetically engineered cell models specifically designed to lack the expression of the GPD2 gene, which encodes glycerol-3-phosphate dehydrogenase 2. This enzyme plays a crucial role in the metabolic pathway of glycerol phosphate in the mitochondria, contributing to lipid metabolism and cellular signaling processes. By creating knockout cell lines, researchers can investigate the functional consequences of GPD2 absence, offering insight into its roles in cellular energy metabolism, proliferation, and apoptosis.

The key functionality of GPD2 gene knockout cell lines lies in their ability to facilitate the study of metabolic disorders and their connections to various diseases, including obesity and type 2 diabetes. This allows scientists to explore the mechanisms underlying these conditions, paving the way for innovative therapeutic interventions. Moreover, these cell lines serve as invaluable tools in drug discovery and development, enabling the assessment of potential therapeutic compounds targeting GPD2-related pathways.

In clinical and research settings, the GPD2 knockout cell lines offer significant advantages over traditional models. Their specificity allows for precise manipulation of metabolic processes, leading to more accurate experimental outcomes. Furthermore, using knockout models demonstrates a higher fidelity to human disease representations compared to wild-type models, enhancing the translational potential of research findings.

For researchers and clinicians interested in metabolic and cardiovascular studies, GPD2 gene knockout cell lines present an unparalleled opportunity to delve into the intricate mechanisms driving human health and disease. These tools allow for comprehensive experimentation and hypothesis testing, leading to impactful scientific discoveries.

Our company specializes in providing high-quality genetic models and is committed to supporting the research community with reliable, innovative tools. With our expertise in biogenetics, we strive to empower researchers in their quest to unlock the complexities of human biology and improve health outcomes through advanced scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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