Gene: GORASP2
Official Full Name: golgi reassembly stacking protein 2provided by HGNC
Gene Summary: This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00322 | GORASP2 Knockout cell line(HEK293) | Human | GORASP2 | 1:3~1:6 | Negative | Online Inquiry |
KO28495 | GORASP2 Knockout cell line (HeLa) | Human | GORASP2 | 1:3~1:6 | Negative | Online Inquiry |
KO28496 | GORASP2 Knockout cell line (HCT 116) | Human | GORASP2 | 1:2~1:4 | Negative | Online Inquiry |
KO28497 | GORASP2 Knockout cell line (A549) | Human | GORASP2 | 1:3~1:4 | Negative | Online Inquiry |
GORASP2 Gene Knockout Cell Lines are expertly engineered cellular models that enable the specific deactivation of the GORASP2 gene, a vital component involved in the regulation of Golgi apparatus function and protein trafficking. By precisely knocking out this gene, researchers can effectively study the downstream effects on cellular processes, providing insights into the biological roles of GORASP2 in cellular homeostasis, Golgi network integrity, and protein maturation.
The key functionality of these knockout cell lines lies in their ability to facilitate detailed functional assays, helping elucidate the molecular pathways affected by GORASP2 dysregulation. This enables an in-depth understanding of the gene’s role in diseases such as cancer and neurological disorders, where Golgi dysfunction is implicated. The mechanism of action stems from the selective disruption of the gene within the appropriate cellular context, ensuring that the observed phenotypic changes are directly correlated with the absence of GORASP2.
From a scientific perspective, GORASP2 Gene Knockout Cell Lines are invaluable tools in both research and clinical settings. They are instrumental for drug discovery, biomarker validation, and the development of therapeutic strategies aimed at diseases correlated with Golgi dysregulation. Researchers can leverage these cell lines to perform high-throughput screening and mechanistic studies, bridging the gap between basic research and translational applications.
Compared to alternative models, the GORASP2 knockout lines offer a unique advantage through their specific targeting of the GORASP2 gene, allowing for precise manipulation of the cellular environment. This specificity reduces off-target effects, leading to more reliable and reproducible experimental outcomes. Moreover, the availability of these knockout lines significantly accelerates research timelines and enhances experimental throughput.
For researchers and clinicians aiming to deepen their understanding of cellular processes or develop novel therapeutic strategies, GORASP2 Gene Knockout Cell Lines represent an essential addition to their toolkit. The ability to explore the ramifications of GORASP2 absence opens avenues for innovative research with implications for understanding complex pathologies.
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Please note that all services are for research use only. Not intended for any clinical use.
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