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GOLGA5 Knockout Cell Lines

Gene: GOLGA5

Official Full Name: golgin A5provided by HGNC

Gene Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05945 GOLGA5 Knockout cell line (HeLa) Human GOLGA5 1:3~1:6 Negative Online Inquiry
KO05946 GOLGA5 Knockout cell line (HCT 116) Human GOLGA5 1:2~1:4 Negative Online Inquiry
KO05947 GOLGA5 Knockout cell line (HEK293) Human GOLGA5 1:3~1:6 Negative Online Inquiry
KO05948 GOLGA5 Knockout cell line (A549) Human GOLGA5 1:3~1:4 Negative Online Inquiry

Background

GOLGA5 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the GOLGA5 gene, which encodes for an important protein involved in Golgi apparatus function and cellular trafficking. By creating knockout cell lines through CRISPR/Cas9 technology, researchers can precisely disrupt the GOLGA5 gene, enabling the examination of the gene's role in various biological processes, including protein sorting, vesicle transport, and cellular signaling pathways.

The key function of these knockout cell lines lies in their ability to reveal compensatory mechanisms and cellular responses resulting from the loss of GOLGA5 expression. Researchers can analyze alterations in cellular morphology, distribution of Golgi apparatus, and overall changes in cellular behavior, providing insights into the implications of GOLGA5 malfunction in disease contexts, particularly in cancerous transformations and other cellular dysfunctions.

From a scientific perspective, GOLGA5 Gene Knockout Cell Lines are invaluable in translational research, drug discovery, and therapeutic development. Their application extends to studying the molecular underpinnings of diseases associated with Golgi apparatus defects, showcasing the essential role of GOLGA5 in maintaining cellular homeostasis.

What sets our product apart from other gene knockout systems is the precision and reliability of our cell lines, paired with robust validation studies that confirm successful gene editing. Each cell line undergoes extensive characterization to ensure minimal off-target effects, enhancing the integrity of your experimental outcomes.

For researchers and clinicians, utilizing GOLGA5 Gene Knockout Cell Lines can accelerate the understanding of disease mechanisms associated with Golgi apparatus dysfunction, ultimately leading to the discovery of novel therapeutic targets. Our commitment to quality and expertise in genetic engineering enhances the value of our offerings, providing researchers with the tools they need to drive innovation in biological research and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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