Gene: GOLGA4
Official Full Name: golgin A4provided by HGNC
Gene Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37575 | GOLGA4 Knockout cell line (HeLa) | Human | GOLGA4 | 1:3~1:6 | Negative | Online Inquiry |
KO37576 | GOLGA4 Knockout cell line (HCT 116) | Human | GOLGA4 | 1:2~1:4 | Negative | Online Inquiry |
KO37577 | GOLGA4 Knockout cell line (HEK293) | Human | GOLGA4 | 1:3~1:6 | Negative | Online Inquiry |
KO37578 | GOLGA4 Knockout cell line (A549) | Human | GOLGA4 | 1:3~1:4 | Negative | Online Inquiry |
GOLGA4 Gene Knockout Cell Lines are highly specialized biological tools designed to facilitate the exploration of gene function and the pathophysiology of various diseases. The GOLGA4 gene, also known as the Golgin A4, is crucial in maintaining Golgi apparatus integrity and intracellular transport processes. These knockout cell lines are engineered to specifically disable the GOLGA4 gene, allowing researchers to investigate the consequences of its absence on cellular behavior, signaling pathways, and overall biological functions.
The primary function of GOLGA4 Gene Knockout Cell Lines lies in their ability to mimic gene deficiencies, providing a robust model for studying the regulatory mechanisms of intracellular trafficking and other Golgi-associated processes. By using CRISPR-Cas9 technology or similar gene-editing methodologies, these cell lines ensure a precise and reproducible deletion of the GOLGA4 gene. The resulting phenotypic changes can be systematically analyzed using various assays, including but not limited to cell migration, apoptosis, and secretion studies.
In scientific research and clinical settings, these cell lines are invaluable for elucidating the roles of GOLGA4 in disease contexts, particularly in cancer, neurodegenerative disorders, and infectious diseases. Understanding the implications of GOLGA4 knockouts could lead to novel therapeutic strategies, drug discovery, and biomarker identification.
Compared to alternative gene knockout models, GOLGA4 Gene Knockout Cell Lines offer unique advantages, including greater specificity, ease of use, and the ability to generate isogenic cell lines for comparative studies. Such features enhance the reliability of experimental outcomes, enabling more definitive conclusions in research.
For researchers and clinicians, the utilization of GOLGA4 Gene Knockout Cell Lines translates into greater insight into gene function, providing a clearer understanding of cellular mechanisms that could be exploited for therapeutic gain. Our company is committed to offering high-quality, well-characterized biological tools that enable cutting-edge research and innovative discoveries in the field of molecular biology and genetics.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.