Gene: GNB3
Official Full Name: G protein subunit beta 3provided by HGNC
Gene Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01340 | GNB3 Knockout cell line (HeLa) | Human | GNB3 | 1:3~1:6 | Negative | Online Inquiry |
KO10340 | GNB3 Knockout cell line (HCT 116) | Human | GNB3 | 1:2~1:4 | Negative | Online Inquiry |
KO10341 | GNB3 Knockout cell line (HEK293) | Human | GNB3 | 1:3~1:6 | Negative | Online Inquiry |
KO10342 | GNB3 Knockout cell line (A549) | Human | GNB3 | 1:3~1:4 | Negative | Online Inquiry |
GNB3 Gene Knockout Cell Lines are specialized cell lines engineered to lack the GNB3 gene, which encodes a protein part of the G protein signaling pathway. This product allows researchers to study the functional role of GNB3 and its implications in various biological processes, including signal transduction, cellular growth, and differentiation. By removing this gene, scientists can observe phenotypic changes and elucidate the mechanisms by which GNB3 contributes to cellular physiology and pathophysiology.
The primary mechanism of these knockout cell lines lies in their ability to mimic specific pathological conditions by removing the gene’s influence, thereby enabling detailed investigations into G protein-coupled receptor (GPCR) signaling pathways. Understanding the role of GNB3 in various cellular contexts can shed light on diseases such as cardiovascular disorders, cancer, and metabolic syndromes. The applications of GNB3 Gene Knockout Cell Lines extend to drug discovery, target validation, and pathway analysis, making them invaluable tools in both research and clinical settings.
One of the key advantages of GNB3 Gene Knockout Cell Lines is their specificity and high reproducibility, which are essential for obtaining reliable experimental results. Unlike general inhibitors or pharmacological agents that may affect multiple pathways, these cell lines provide a precise approach to investigating the effects of GNB3 knockdown without off-target effects. This specificity enhances the reliability of data and accelerates the pace of discovery.
For researchers and clinicians, these cell lines offer the opportunity to delve deeper into the intricacies of G protein signaling, ultimately paving the way for novel therapeutic strategies. Utilizing GNB3 Gene Knockout Cell Lines can enhance the understanding of complex biological systems and foster the development of targeted interventions.
Our company excels in providing high-quality biological products, including these specialized knockout cell lines, backed by rigorous validation and extensive support, ensuring that researchers have the resources they need to advance their work effectively and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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