Gene: GNB1
Official Full Name: G protein subunit beta 1provided by HGNC
Gene Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01342 | GNB1 Knockout cell line (HeLa) | Human | GNB1 | 1:3~1:6 | Negative | Online Inquiry |
KO10346 | GNB1 Knockout cell line (HCT 116) | Human | GNB1 | 1:2~1:4 | Negative | Online Inquiry |
KO10347 | GNB1 Knockout cell line (HEK293) | Human | GNB1 | 1:3~1:6 | Negative | Online Inquiry |
KO10348 | GNB1 Knockout cell line (A549) | Human | GNB1 | 1:3~1:4 | Negative | Online Inquiry |
GNB1 Gene Knockout Cell Lines are specialized cell models that have been genetically engineered to disrupt the expression of the GNB1 gene, which encodes the beta subunit of the heterotrimeric G protein complex. This crucial modification allows researchers to study the biological roles of GNB1 in cellular signaling pathways and its contributions to various physiological processes.
The key function of these knockout cell lines lies in their ability to enhance our understanding of G protein-coupled receptor (GPCR) signaling, which is fundamental in numerous cellular responses including neurotransmission, hormonal signaling, and cell growth regulation. By leveraging these cell lines, researchers can elucidate the downstream effects of GNB1 disruption, allowing for robust studies on cellular behavior, drug response, and pathophysiological conditions linked to aberrant signaling.
Scientifically, GNB1 Gene Knockout Cell Lines serve as invaluable tools in both fundamental and applied research settings. They are particularly relevant in the investigation of cancers, neurological disorders, and metabolic diseases, where GPCR pathways are often dysregulated. Their application extends to drug screening platforms and the development of novel therapeutic interventions aimed at modulating G protein signaling.
What sets our GNB1 Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability, achieved through the use of advanced CRISPR-Cas9 technology. This ensures a precise knockout with minimal off-target effects, thus providing a more accurate representation of the role of GNB1 in vivo. Additionally, our extensive characterization and validation of these cell lines guarantee reproducibility and consistency across experiments.
For researchers and clinicians, the value of utilizing GNB1 Gene Knockout Cell Lines lies in the empowered ability to dissect complex signaling networks and the potential to develop new strategies for disease intervention. This product not only advances scientific understanding but also fosters innovation in therapeutic development.
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Please note that all services are for research use only. Not intended for any clinical use.
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