Gene: GMEB1
Official Full Name: glucocorticoid modulatory element binding protein 1provided by HGNC
Gene Summary: This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31611 | GMEB1 Knockout cell line (HeLa) | Human | GMEB1 | 1:3~1:6 | Negative | Online Inquiry |
KO31612 | GMEB1 Knockout cell line (HCT 116) | Human | GMEB1 | 1:2~1:4 | Negative | Online Inquiry |
KO31613 | GMEB1 Knockout cell line (HEK293) | Human | GMEB1 | 1:3~1:6 | Negative | Online Inquiry |
KO31614 | GMEB1 Knockout cell line (A549) | Human | GMEB1 | 1:3~1:4 | Negative | Online Inquiry |
GMEB1 Gene Knockout Cell Lines are specialized cellular models in which the GMEB1 gene has been precisely inactivated, providing invaluable tools for investigating the biological functions of this gene in various biological processes. GMEB1 is known to encode for a transcription factor that plays a critical role in gene regulation, cell cycle progression, and various stress responses. The knockout of this gene allows researchers to elucidate its role in cellular mechanisms and to better understand the phenotypic consequences of GMEB1 loss, thereby enhancing our comprehension of diseases where GMEB1 may be implicated.
These cell lines operate through the mechanism of gene editing, primarily using CRISPR/Cas9 technology, to create targeted genetic deletions or disruptions. By eliminating GMEB1 expression, users can assess alterations in cellular pathways, signaling cascades, and overall cellular behavior, making the GMEB1 knockout model an essential tool for research in oncology, developmental biology, and molecular genetics.
The scientific importance of GMEB1 gene knockout cell lines extends into both academic research and clinical settings. In the context of cancer research, for example, understanding the downstream effects of GMEB1 in tumorigenesis may lead to novel therapeutic targets. Moreover, these models can be used in drug discovery processes to assess compound efficacy or toxicity in the absence of GMEB1, thereby contributing to the development of safer and more effective treatments.
Compared to other gene knockout technologies, our GMEB1 cell lines provide a streamlined and efficient approach for researchers. They come fully validated for consistent performance and are ready-to-use, reducing the time and cost associated with establishing new models. Furthermore, we offer extensive support and protocols to facilitate experimental design and implementation.
For researchers and clinicians focused on unraveling the complexities of gene function and its implications for human health, GMEB1 Gene Knockout Cell Lines offer a robust and reliable option. Our company specializes in high-quality biological products and has a proven track record of innovation and reliability in the field. By choosing our GMEB1 knockout cell lines, users align themselves with an industry leader committed to advancing scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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