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GLIS1 Knockout Cell Lines

Gene: GLIS1

Official Full Name: GLIS family zinc finger 1provided by HGNC

Gene Summary: GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23158 GLIS1 Knockout cell line (HeLa) Human GLIS1 1:3~1:6 Negative Online Inquiry
KO23159 GLIS1 Knockout cell line (HEK293) Human GLIS1 1:3~1:6 Negative Online Inquiry

Background

GLIS1 Gene Knockout Cell Lines represent a pioneering advancement in genetic research, designed specifically to facilitate the in-depth study of the GLIS1 gene, known for its significant roles in cellular regulation, development, and potential links to various diseases, including metabolic syndrome and cancer. These engineered cell lines are characterized by the targeted disruption of the GLIS1 gene, achieved through precise gene editing techniques such as CRISPR/Cas9, allowing researchers to explore the gene's function and regulatory mechanisms in a controlled environment.

The core function of GLIS1 Gene Knockout Cell Lines lies in their ability to mimic the loss-of-function scenarios that occur in pathological conditions. By providing a model wherein GLIS1 is no longer expressed, researchers can study the downstream effects on signaling pathways involved in cell proliferation, differentiation, and apoptosis. This model is particularly valuable in understanding the gene's role in tissue homeostasis and its implications in various diseases.

From a scientific perspective, these cell lines serve as indispensable tools for both basic and applied research. They enable investigators to assess therapeutic targets, evaluate drug efficacy, and investigate the gene's embryonic development contributions, thereby offering insights that could lead to novel interventions for diseases linked to GLIS1 dysfunction.

One significant advantage of our GLIS1 Gene Knockout Cell Lines is their rigorously validated genomic integrity and phenotypic stability, ensuring that experimental results are both reproducible and reliable. Compared to alternative models, including transient knockdown techniques, these knockout lines provide more consistent and long-term results, allowing for prolonged studies without the complications associated with transient gene editing.

Researchers and clinicians benefit immensely from these cell lines, as they enhance the capacity to delineate disease mechanisms, identify novel biomarkers, and develop gene-targeted therapies. Our commitment to quality and innovation ensures that users receive products that not only meet high scientific standards but also advance the frontiers of genetic research.

With a robust background in producing advanced genetic models, our company stands at the forefront of biotechnology, offering a comprehensive portfolio designed to empower scientific discovery and clinical application.

Please note that all services are for research use only. Not intended for any clinical use.

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