Gene: GKN2
Official Full Name: gastrokine 2provided by HGNC
Gene Summary: The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38069 | GKN2 Knockout cell line (A549) | Human | GKN2 | 1:3~1:4 | Negative | Online Inquiry |
GKN2 Gene Knockout Cell Lines are specifically engineered cellular models that have been genetically modified to disrupt the expression of the GKN2 gene, a critical component involved in a variety of physiological processes, including gastrointestinal health and inflammation. This biotechnology product facilitates the study of GKN2's functional roles by providing researchers with a controlled environment to evaluate the downstream effects of gene knockout in cellular pathways.
The key mechanism by which GKN2 Gene Knockout Cell Lines operate involves the application of CRISPR-Cas9 gene editing technology, which selectively targets and induces double-strand breaks in the GKN2 genomic locus. This leads to the deletion or disruption of the gene, resulting in loss of gene function. By utilizing these knockout models, researchers can assess not only the biological consequences of GKN2 deficiency but also explore the implications in conditions such as gastric cancer, ulcerative colitis, and other gastrointestinal disorders.
The scientific importance of GKN2 Gene Knockout Cell Lines lies in their applicability in both basic and translational research. They serve as invaluable tools for understanding gene function, elucidating disease mechanisms, and screening potential therapeutics. The capability to study the GKN2 gene in isolation enhances the precision of data gained from experimental approaches, leading to more reliable and reproducible results.
Compared to traditional cell lines, GKN2 Gene Knockout Cell Lines provide several advantages: they offer specificity in gene manipulation, enable more accurate modeling of disease phenotypes, and support the generation of data that can lead to innovative drug discovery. Their use simplifies the process of investigating gene-related pathways, which is often complicated in wild-type cell lines that harbor functional gene expression.
Researchers, clinicians, and biopharmaceutical industries will find these knockout cell lines invaluable in addressing current gaps in understanding GKN2-related pathways and developing targeted therapeutic approaches. With their ability to provide insights into gene function and pathology, these cell lines are essential for paving the way toward advancements in therapeutic strategies.
Our company specializes in the design and development of high-quality genetic tools, backed by a dedicated team of experts with extensive experience in gene editing and cellular biology, ensuring that our products meet the rigorous standards required for cutting-edge research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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