Gene: GFM2
Official Full Name: GTP dependent ribosome recycling factor mitochondrial 2provided by HGNC
Gene Summary: Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24904 | GFM2 Knockout cell line (HeLa) | Human | GFM2 | 1:3~1:6 | Negative | Online Inquiry |
KO24905 | GFM2 Knockout cell line (HCT 116) | Human | GFM2 | 1:2~1:4 | Negative | Online Inquiry |
KO24906 | GFM2 Knockout cell line (HEK293) | Human | GFM2 | 1:3~1:6 | Negative | Online Inquiry |
KO24907 | GFM2 Knockout cell line (A549) | Human | GFM2 | 1:3~1:4 | Negative | Online Inquiry |
GFM2 Gene Knockout Cell Lines are specialized cell cultures designed to facilitate the study of the GFM2 gene, known for its critical role in various cellular processes, including mitochondrial function and translation fidelity. These cell lines have been genetically engineered to specifically disrupt the GFM2 gene, providing researchers with a powerful tool to investigate the molecular pathways and physiological implications associated with its loss of function.
The functionality of GFM2 Gene Knockout Cell Lines is rooted in their ability to mimic pathological states that occur when GFM2 is nonfunctional. By employing techniques such as CRISPR-Cas9 technology for gene editing, these cell lines allow for precise modifications, enabling investigators to explore the gene's role in metabolic regulation, cellular stress response, and disease modeling. Moreover, the knockouts exhibit changes in both cellular metabolism and mitochondrial dynamics, making them relevant for studies on metabolic diseases, neurological disorders, and cancer.
The scientific importance of these cell lines cannot be overstated, as they provide insights into the fundamental biological processes and associated diseases linked to GFM2 dysfunction. They are particularly valuable in both basic research and therapeutic investigations, allowing for the development of targeted interventions aimed at correcting or compensating for gene-mediated pathologies.
In comparison to alternatives such as transient knockdown models, GFM2 Gene Knockout Cell Lines offer several advantages: including stable expression, reproducibility, and the ability to conduct long-term experiments. These characteristics contribute to more reliable data and enhanced understanding of gene function over time.
For researchers and clinicians focused on genetic and metabolic studies, GFM2 Gene Knockout Cell Lines hold significant promise. They represent a robust platform for experimental insights, paving the way for potential therapeutic strategies and advancements in precision medicine.
Our company specializes in providing high-quality, rigorously validated biological products. With extensive expertise in gene editing technologies, we are committed to supporting the scientific community’s efforts in advancing research and healthcare solutions through innovative genetic tools.
Please note that all services are for research use only. Not intended for any clinical use.
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