Gene: GET3
Official Full Name: guided entry of tail-anchored proteins factor 3, ATPaseprovided by HGNC
Gene Summary: This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38895 | GET3 Knockout cell line (HeLa) | Human | GET3 | 1:3~1:6 | Negative | Online Inquiry |
KO38896 | GET3 Knockout cell line (HCT 116) | Human | GET3 | 1:2~1:4 | Negative | Online Inquiry |
KO38897 | GET3 Knockout cell line (HEK293) | Human | GET3 | 1:3~1:6 | Negative | Online Inquiry |
KO38898 | GET3 Knockout cell line (A549) | Human | GET3 | 1:3~1:4 | Negative | Online Inquiry |
GET3 Gene Knockout Cell Lines represent a cutting-edge resource in the field of genetic research, specifically designed to facilitate the study of gene function and regulation through targeted gene disruption. These cell lines are engineered to lack the GET3 gene, a component critically involved in protein transport and endoplasmic reticulum-associated degradation pathways. By employing CRISPR-Cas9 technology or other genome-editing methods, GET3 knockout models allow researchers to explore the downstream effects of GET3 absence on cellular processes and phenotypes, enhancing our understanding of protein homeostasis and cellular stress responses.
The key mechanism of action relies on the precise deletion of the GET3 gene, resulting in the disruption of its associated biological pathways. This knockout enables researchers to study the implications of GET3 deficiency in a controlled environment, providing valuable insights into potential compensatory mechanisms and alternative pathways activated during stress conditions.
Scientifically, GET3 Gene Knockout Cell Lines are instrumental in various research applications, including drug discovery, disease modeling, and the investigation of genetic abnormalities. Their utilization extends to studying neurodegenerative diseases and metabolic disorders where protein misfolding and transport are critical factors. Furthermore, these cell lines serve as an essential tool in the validation of therapeutic targets and the exploration of gene therapy strategies.
What sets GET3 Gene Knockout Cell Lines apart from other products on the market is their comprehensive characterization and ease of use. Each line is provided with detailed data regarding genetic alterations, cellular behavior, and viability, allowing researchers to select the most appropriate model for their specific needs. Furthermore, our commitment to quality ensures that these cell lines are rigorously tested for consistency and reproducibility.
For researchers and clinicians seeking reliable tools to unlock the complexities of genetic regulation, GET3 Gene Knockout Cell Lines offer unparalleled value. Our company prides itself on being at the forefront of genetic engineering technology, providing researchers with innovative products that drive scientific progress and enhance experimental outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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