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GALNT6 Knockout Cell Lines

Gene: GALNT6

Official Full Name: polypeptide N-acetylgalactosaminyltransferase 6provided by HGNC

Gene Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31056 GALNT6 Knockout cell line (HCT 116) Human GALNT6 1:2~1:4 Negative Online Inquiry
KO31057 GALNT6 Knockout cell line (HEK293) Human GALNT6 1:3~1:6 Negative Online Inquiry
KO31058 GALNT6 Knockout cell line (A549) Human GALNT6 1:3~1:4 Negative Online Inquiry

Background

GALNT6 Gene Knockout Cell Lines are specialized laboratory models created by the targeted disruption of the GALNT6 gene, which encodes an N-acetylgalactosaminyltransferase enzyme involved in O-glycosylation processes. These cell lines serve as invaluable tools for studying the biological implications of GALNT6 in cancer progression, immune response, and other pathological conditions where altered glycosylation patterns are pivotal. The knockout mechanism is typically facilitated through CRISPR-Cas9 technology, ensuring precision and efficiency in gene editing, providing researchers with a reliable model for functional analysis.

The primary function of GALNT6 gene knockout is to elucidate its role in cellular pathways and mechanisms that are integral to glycosylation. By examining how the absence of GALNT6 affects protein structure, cellular signaling, and tumor cell behavior, researchers can draw connections to disease mechanisms and potential therapeutic targets. This functional assessment can lead to significant discoveries in cancer biology, as aberrant glycosylation is frequently linked with tumor metastasis and immune evasion.

The scientific importance of these knockout cell lines extends to various research applications, including drug discovery, biomarker identification, and functional genomics. The specificity of GALNT6 knockout supports robust in vitro assays that can generate relevant data for both academia and industry, making them highly sought after in translational research environments.

Compared to alternative gene editing products, the GALNT6 Gene Knockout Cell Lines offer unique advantages such as characterized genetic stability, reproducible results, and ease of use across a range of experimental conditions. Additionally, the precise nature of CRISPR-Cas9 technology minimizes off-target effects, providing confidence in the validity of research outcomes.

For researchers and clinicians focused on glycosylation and its implications in human health, the GALNT6 Gene Knockout Cell Lines present a critical resource. They facilitate innovative research pathways that can drive significant advancements in understanding disease mechanisms and developing targeted therapies.

Our company prides itself on being at the forefront of gene editing technologies and providing high-quality biological products tailored to meet the needs of the scientific community. Our expertise in developing and validating these cell lines ensures that you have access to valuable tools that can accelerate your research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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