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GALNT3 Knockout Cell Lines

Gene: GALNT3

Official Full Name: polypeptide N-acetylgalactosaminyltransferase 3provided by HGNC

Gene Summary: This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37734 GALNT3 Knockout cell line (HeLa) Human GALNT3 1:3~1:6 Negative Online Inquiry
KO37735 GALNT3 Knockout cell line (HCT 116) Human GALNT3 1:2~1:4 Negative Online Inquiry
KO37736 GALNT3 Knockout cell line (HEK293) Human GALNT3 1:3~1:6 Negative Online Inquiry

Background

GALNT3 Gene Knockout Cell Lines represent a groundbreaking tool in biological research, specifically designed to investigate the role of the GALNT3 gene, which encodes for a glycosyltransferase involved in O-linked glycosylation. These cell lines have been engineered using advanced CRISPR-Cas9 technology to precisely disrupt the GALNT3 gene, creating a model that allows researchers to examine the functional consequences of GALNT3 loss. This enables a deeper understanding of its implications in various biological processes and diseases, notably in the context of metabolic disorders and tumorigenesis.

The primary mechanism of these knockout cell lines revolves around the specific deletion of the GALNT3 gene, effectively abolishing the synthesis of the corresponding glycosylation products. By studying these modifications—or lack thereof—scientists can elucidate the pathways influenced by GALNT3, potentially uncovering novel insights related to diseases such as cancer and congenital disorders.

The scientific importance of GALNT3 Gene Knockout Cell Lines cannot be overstated, as they provide invaluable insights into the genetic and biochemical pathways that are critical for both basic research and clinical applications. Researchers can leverage these cell lines to test therapeutic interventions, investigate drug responses, or even explore compensatory mechanisms triggered by the gene's absence.

Compared to conventional cell lines, these knockout models offer unmatched specificity and reliability in studying GALNT3-related functions. Traditional models may yield confounding results due to the presence of functional gene copies or variations in expression levels. The precision of CRISPR-mediated knockout ensures that researchers work with a homogenous population of cells, affording more robust and reproducible data.

The value of GALNT3 Gene Knockout Cell Lines for researchers and clinicians is clear; they provide an essential platform for exploring genetic influences on disease mechanisms and therapeutic responses, facilitating breakthroughs in personalized medicine strategies and targeted therapies.

With years of expertise in genetic engineering and cell line development, our company is dedicated to providing cutting-edge tools that empower the scientific community and enhance research capabilities. By offering high-quality GALNT3 Gene Knockout Cell Lines, we aim to support advancements in biomedical research that drive innovation and improve clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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