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GAGE6 Knockout Cell Lines

Gene: GAGE6

Official Full Name: G antigen 6provided by HGNC

Gene Summary: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37761 GAGE6 Knockout cell line (HeLa) Human GAGE6 1:3~1:6 Negative Online Inquiry
KO37762 GAGE6 Knockout cell line (HCT 116) Human GAGE6 1:2~1:4 Negative Online Inquiry
KO37763 GAGE6 Knockout cell line (HEK293) Human GAGE6 1:3~1:6 Negative Online Inquiry
KO37764 GAGE6 Knockout cell line (A549) Human GAGE6 1:3~1:4 Negative Online Inquiry

Background

GAGE6 Gene Knockout Cell Lines are a cutting-edge biological product designed for advanced research on gene function, cellular signaling pathways, and therapeutic development. These cell lines have been engineered to specifically knock out the GAGE6 gene, which is known to play a crucial role in cancer immunology and male germ cell development. By utilizing CRISPR-Cas9 technology, these cell lines allow researchers to precisely examine the consequences of GAGE6 loss-of-function on cellular behavior.

The primary mechanism of action relies on the targeted disruption of the GAGE6 gene, leading to a lack of expression of its associated proteins. This creates a controlled environment for scientists to investigate the downstream effects on cellular processes such as apoptosis, proliferation, and response to immunotherapies. Importantly, the GAGE6 protein is also implicated in tumorigenesis; thus, studying these knockout cell lines can contribute valuable insights into cancer biology and potentially lead to novel therapeutic strategies.

In terms of scientific importance, GAGE6 Gene Knockout Cell Lines offer unique applications in both research and clinical settings. They enable in-depth studies on the roles of cancer/testis antigens in immune evasion and tumor microenvironment interactions, making them an essential tool for oncologists and immunologists studying tumor immunology.

Compared to traditional gene editing techniques, our GAGE6 Gene Knockout Cell Lines provide a valuable advantage due to their ease of use and reproducibility, allowing for quick adaptation in various laboratory protocols. Additionally, these cell lines come with extensive validation data, ensuring reliability and consistency for researchers seeking to make significant contributions to their fields.

Ultimately, GAGE6 Gene Knockout Cell Lines represent a vital resource for researchers and clinicians dedicated to unraveling the complexities of gene function and disease mechanisms. Leveraging our extensive expertise in cellular model development, we are committed to providing high-quality biological research tools that facilitate groundbreaking discoveries in genomics, oncology, and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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