Gene: G3BP1
Official Full Name: G3BP stress granule assembly factor 1provided by HGNC
Gene Summary: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17507 | G3BP1 Knockout cell line (HeLa) | Human | G3BP1 | 1:3~1:6 | Negative | Online Inquiry |
KO17508 | G3BP1 Knockout cell line (HCT 116) | Human | G3BP1 | 1:2~1:4 | Negative | Online Inquiry |
KO17509 | G3BP1 Knockout cell line (HEK293) | Human | G3BP1 | 1:3~1:6 | Negative | Online Inquiry |
KO17510 | G3BP1 Knockout cell line (A549) | Human | G3BP1 | 1:3~1:4 | Negative | Online Inquiry |
G3BP1 Gene Knockout Cell Lines are genetically engineered models designed to facilitate the study of the G3BP1 gene, a critical player in cellular stress response and mRNA regulation. G3BP1 functions as a key component in the formation of stress granules, structures that sequester mRNA and proteins during cellular stress events. By knocking out this gene, researchers can examine the metabolic and functional consequences of G3BP1 loss, providing valuable insights into its role in various biological processes including cellular signaling, apoptosis, and inflammation.
The mechanism of action involves the complete elimination of G3BP1 expression in the cell line, which allows for a controlled environment to study the cellular pathways affected by its absence. This knockout model can be utilized to assess changes in stress granule dynamics, mRNA stability, and the overall cellular adaptability to stress conditions, enabling researchers to gain deeper understanding of diseases linked to G3BP1 dysfunction, such as neurodegeneration and cancer.
The scientific importance of G3BP1 Gene Knockout Cell Lines lies in their broad applications in basic research, drug discovery, and therapeutic development. These models are especially beneficial for elucidating the molecular underpinnings of stress response mechanisms and investigating potential treatment strategies for diseases associated with G3BP1 misregulation.
What distinguishes G3BP1 Gene Knockout Cell Lines from alternatives is their reliability and standardization, reducing variability in experimental outcomes. Our cell lines are generated through cutting-edge CRISPR technology, ensuring a precise genetic modification which enhances reproducibility in research findings. Moreover, they are validated for key traits, including growth characteristics and response to perturbations, making them a trusted choice for both academic and clinical research settings.
For researchers and clinicians aiming to deepen their understanding of cellular stress responses or develop innovative treatments, G3BP1 Gene Knockout Cell Lines offer an invaluable resource. At our company, we are committed to advancing research through high-quality biological products, underpinned by our expertise in genetic engineering and cell biology. Our dedication to scientific excellence ensures that our offerings support the scientific community in achieving groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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