Gene: FZD7
Official Full Name: frizzled class receptor 7provided by HGNC
Gene Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11754 | FZD7 Knockout cell line (HeLa) | Human | FZD7 | 1:3~1:6 | Negative | Online Inquiry |
KO11755 | FZD7 Knockout cell line (HCT 116) | Human | FZD7 | 1:2~1:4 | Negative | Online Inquiry |
KO11756 | FZD7 Knockout cell line (HEK293) | Human | FZD7 | 1:3~1:6 | Negative | Online Inquiry |
KO11757 | FZD7 Knockout cell line (A549) | Human | FZD7 | 1:3~1:4 | Negative | Online Inquiry |
FZD7 Gene Knockout Cell Lines are specialized cell lines designed to facilitate the study of the Frizzled-7 (FZD7) gene's role in various biological processes and diseases. FZD7 is a member of the Wnt signaling pathway, which is crucial in cellular communication, differentiation, and development. By creating knockout models that lack functional FZD7 expression, researchers can observe the resultant phenotypic changes and better understand the gene’s specific functions in health and disease.
These cell lines enable the analysis of the underlying mechanisms by which FZD7 contributes to important pathways, including cell proliferation, apoptosis, and tumorigenesis. The absence of FZD7 allows scientists to dissect its role not only in normal cellular functions but also in the context of cancer and regenerative medicine. They can use these cell lines to elucidate the gene's interactions with other signaling pathways and its potential as a therapeutic target.
The scientific importance of FZD7 gene knockout cell lines cannot be overstated, as they provide a reliable in vitro model for a wide range of applications, from basic research to drug discovery. The unique selling points of this product include the precision and reliability it offers through well-characterized knockout models, which often outperform traditional methods, such as RNA interference.
Moreover, researchers benefit from the availability of validated cell lines that can streamline experimental workflows and improve reproducibility. For clinicians and pharmaceutical developers, these insights contribute to a more profound understanding of FZD7’s role in pathophysiological processes, paving the way for the development of targeted treatments.
Our company prides itself on its commitment to advancing scientific research through high-quality biological products. With extensive expertise in genetic engineering and cell line development, we are dedicated to providing researchers with the tools necessary to explore the complexities of molecular biology and enhance their discovery processes.
Please note that all services are for research use only. Not intended for any clinical use.
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