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FUZ Knockout Cell Lines

Gene: FUZ

Official Full Name: fuzzy planar cell polarity proteinprovided by HGNC

Gene Summary: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26147 FUZ Knockout cell line (HeLa) Human FUZ 1:3~1:6 Negative Online Inquiry
KO26148 FUZ Knockout cell line (HCT 116) Human FUZ 1:2~1:4 Negative Online Inquiry
KO26149 FUZ Knockout cell line (HEK293) Human FUZ 1:3~1:6 Negative Online Inquiry
KO26150 FUZ Knockout cell line (A549) Human FUZ 1:3~1:4 Negative Online Inquiry

Background

FUZ Gene Knockout Cell Lines represent a significant innovation in the field of cellular and molecular biology, specifically designed to facilitate the study of gene function and associated biological pathways. These cell lines have been meticulously engineered through CRISPR/Cas9 technology to selectively disrupt the FUZ gene, which encodes the protein Fuz, an essential component in various cellular processes including cilia formation and Wnt signaling pathways. By knocking out this gene, researchers can directly observe the phenotypic consequences, thereby elucidating the role of Fuz in developmental biology and disease mechanisms.

The primary mechanism behind FUZ Gene Knockout Cell Lines involves a precise modification of the genomic sequence targeting the FUZ gene. This alteration leads to a loss of function, allowing investigators to analyze cellular behaviors, signal transduction events, and developmental phenomena that are typically mediated by the Fuz protein. The resultant alterations in cellular morphology or function serve as a window into the underlying biological processes, making these knockout lines invaluable for both basic research and therapeutic investigations.

In scientific research and clinical applications, these knockout cell lines possess significant importance. They serve as pivotal tools for exploring gene function in oncogenesis, neurodevelopmental disorders, and ciliopathies, among other conditions. Furthermore, with the increasing reliance on precision medicine, the ability to study genes in the context of specific pathways offers a roadmap towards more targeted treatment strategies.

What sets FUZ Gene Knockout Cell Lines apart from existing products is their rigorous validation, consistent performance, and ease of use. Each cell line comes with detailed characterization data and optimized culture conditions, streamlining the workflow for researchers. The ability to produce versatile experimental designs while ensuring reproducibility is a critical advantage that addresses common challenges in genetic research.

Moreover, the ability to directly manipulate gene expression in a highly controlled manner equips researchers and clinicians alike with the tools necessary to dissect complex biological questions and translate discoveries into clinical insights. This is a testament to the growing need for advanced models that embody relevance to human health and illness.

Our company, with its extensive expertise in gene editing technologies and commitment to high-quality biological products, is dedicated to providing researchers with solutions that empower their investigations. The FUZ Gene Knockout Cell Lines exemplify this commitment, offering unmatched reliability and insight to support cutting-edge research across various scientific domains.

Please note that all services are for research use only. Not intended for any clinical use.

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