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FUBP1 Knockout Cell Lines

Gene: FUBP1

Official Full Name: far upstream element binding protein 1provided by HGNC

Gene Summary: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33759 FUBP1 Knockout cell line (HeLa) Human FUBP1 1:3~1:6 Negative Online Inquiry
KO33760 FUBP1 Knockout cell line (HCT 116) Human FUBP1 1:2~1:4 Negative Online Inquiry
KO33761 FUBP1 Knockout cell line (HEK293) Human FUBP1 1:3~1:6 Negative Online Inquiry
KO33762 FUBP1 Knockout cell line (A549) Human FUBP1 1:3~1:4 Negative Online Inquiry

Background

FUBP1 Gene Knockout Cell Lines represent a cutting-edge tool in genetic research, engineered to lack the FUBP1 gene, which encodes the far-upstream element-binding protein 1. This key regulatory protein plays a critical role in cell proliferation, differentiation, and RNA processing. By utilizing these knockout cell lines, researchers can investigate the functional consequences of FUBP1 deficiency, enabling a deeper understanding of its involvement in various biological processes and disease states.

The FUBP1 gene knockout is achieved through advanced gene-editing techniques such as CRISPR/Cas9, which precisely disrupts the FUBP1 gene. This disruption leads to alterations in downstream signaling pathways and gene expression profiles, allowing researchers to probe the molecular mechanisms by which FUBP1 influences cellular behavior. The ability to manipulate the FUBP1 gene equips scientists with a powerful platform to explore its implications in conditions such as cancer, neurodegenerative diseases, and metabolic disorders.

The scientific importance of FUBP1 Gene Knockout Cell Lines is underlined by their vast applications in both research and clinical settings. For instance, they can be used in drug discovery programs aimed at identifying novel therapeutic targets or validating the efficacy of new compounds. Furthermore, they serve as valuable models for studying the role of FUBP1 in responses to environmental stressors or pharmacological interventions, providing insights that could lead to improved treatment strategies.

One notable advantage of our FUBP1 Gene Knockout Cell Lines is the consistency and reproducibility they offer, which are crucial for high-quality experimental outcomes. Unlike other alternatives that may exhibit variable genetic backgrounds or inadvertent off-target effects, our cell lines come from a well-characterized platform, ensuring reliable and precise experimental results. In addition, these cell lines are compatible with a variety of assays, including but not limited to gene expression analysis, protein interaction studies, and cellular function assays, providing versatility for a wide range of research applications.

For researchers and clinicians focused on unraveling the complexities of gene function and its impact on health and disease, FUBP1 Gene Knockout Cell Lines demonstrate significant value. They not only expedite the research process but also enhance the translation of laboratory findings into clinical settings.

Our company specializes in providing high-quality biological products tailored for the scientific community. With a commitment to innovation and excellence, we ensure that our offerings, including the FUBP1 Gene Knockout Cell Lines, empower researchers to push the boundaries of discovery and therapeutic advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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