Gene: FRG1
Official Full Name: FSHD region gene 1provided by HGNC
Gene Summary: This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37811 | FRG1 Knockout cell line (HeLa) | Human | FRG1 | 1:3~1:6 | Negative | Online Inquiry |
KO37812 | FRG1 Knockout cell line (HCT 116) | Human | FRG1 | 1:2~1:4 | Negative | Online Inquiry |
KO37813 | FRG1 Knockout cell line (HEK293) | Human | FRG1 | 1:3~1:6 | Negative | Online Inquiry |
KO37814 | FRG1 Knockout cell line (A549) | Human | FRG1 | 1:3~1:4 | Negative | Online Inquiry |
FRG1 Gene Knockout Cell Lines are engineered cellular models specifically designed for the knockout of the FRG1 gene, which has been implicated in various biological processes and disease states, including neuromuscular disorders. By removing the functional FRG1 gene, these cell lines facilitate the investigation of gene function and its impact on cellular mechanisms, particularly in muscle development and maintenance. Utilizing CRISPR-Cas9 genome editing technology, these cell lines exhibit precise gene modification, providing researchers with robust tools to study not only the direct effects of FRG1 loss but also the downstream consequences on cellular pathways.
The primary functionalities of FRG1 Gene Knockout Cell Lines revolve around their ability to model specific phenotypic traits associated with FRG1 deficiencies. Researchers can observe cellular behavior in both normal and mutated states, examining alterations in proliferation, differentiation, and apoptosis. The implications of these studies extend to better understanding the molecular underpinnings of diseases linked to FRG1, paving pathways for targeted therapeutic approaches in clinical settings.
Compared to conventional knockout models, which often have limitations in fidelity and context-specific expression, FRG1 Gene Knockout Cell Lines offer specialized advantages such as high efficiency in gene ablation and adaptability in various experimental conditions. This precision aids in reducing variability and improving reproducibility in research findings.
As a result, these cell lines prove invaluable for researchers and clinicians focusing on muscular dystrophies and related conditions. They not only serve as essential tools in drug discovery and target validation but also enhance the translational potential of research findings into clinical applications.
Our company specializes in high-quality cellular models and gene editing solutions, ensuring that our FRG1 Gene Knockout Cell Lines are rigorously validated for scientific accuracy and reliability. This commitment to excellence equips researchers with the resources necessary to advance their understanding of complex biological systems and develop innovative therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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