Gene: FOSB
Official Full Name: FosB proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
Gene Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37837 | FOSB Knockout cell line (HCT 116) | Human | FOSB | 1:2~1:4 | Negative | Online Inquiry |
KO37838 | FOSB Knockout cell line (HEK293) | Human | FOSB | 1:3~1:6 | Negative | Online Inquiry |
KO37839 | FOSB Knockout cell line (A549) | Human | FOSB | 1:3~1:4 | Negative | Online Inquiry |
FOSB Gene Knockout Cell Lines are genetically engineered cell models that have had the FOSB gene functionally disrupted, enabling researchers to study the biological implications of FOSB's role in various cellular processes. The FOSB gene encodes a member of the Fos family of proteins, which are known to be implicated in regulating cellular proliferation, differentiation, and response to stress. By creating knockout cell lines, researchers can observe the impact of the absence of FOSB on signaling pathways, gene expression, and cellular behavior, providing insights that are critical for understanding diseases such as cancer.
The key function of these knockout cell lines lies in their ability to elucidate the mechanisms through which FOSB contributes to cellular dynamics. The absence of FOSB allows for the investigation of compensatory signaling mechanisms and the cross-talk between pathways that may contribute to oncogenesis or resistance to therapy. These cell lines serve as powerful tools in the field of cancer research and beyond, allowing for the development of targeted therapeutic strategies.
The scientific importance of FOSB Gene Knockout Cell Lines extends to their applications in both research and clinical settings, including basic research into signal transduction, investigation of transcriptional regulation, and the development of biomarker discovery platforms. Furthermore, these knockout cell lines can facilitate drug development by providing a platform to test compounds that may interfere with or modulate the activities of FOSB-related pathways.
When compared to alternative methods, such as transient transfection or RNA interference, FOSB Gene Knockout Cell Lines offer the advantage of stable genetic modification, resulting in consistent and reproducible experimental results. This stability reduces variability and enhances the reliability of findings, making it easier to draw conclusions that are applicable to real biological systems.
For researchers and clinicians aiming to explore the nuances of FOSB's role in health and disease, these genetically modified cell lines represent a critical resource. By utilizing these tools, potential therapeutic avenues can be investigated, contributing to advancements in patient care and treatment methodologies.
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