Gene: FNIP2
Official Full Name: folliculin interacting protein 2provided by HGNC
Gene Summary: This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09221 | FNIP2 Knockout cell line (HeLa) | Human | FNIP2 | 1:3~1:6 | Negative | Online Inquiry |
KO09222 | FNIP2 Knockout cell line (HCT 116) | Human | FNIP2 | 1:2~1:4 | Negative | Online Inquiry |
KO09223 | FNIP2 Knockout cell line (HEK293) | Human | FNIP2 | 1:3~1:6 | Negative | Online Inquiry |
KO09224 | FNIP2 Knockout cell line (A549) | Human | FNIP2 | 1:3~1:4 | Negative | Online Inquiry |
FNIP2 Gene Knockout Cell Lines consist of genetically modified cell lines in which the FNIP2 (FAT1 and NF1-Interacting Protein 2) gene has been selectively disrupted. These cell lines serve as vital experimental tools for investigating the functional role of FNIP2 in various biological processes, including cellular metabolism, signal transduction, and oncogenesis. By creating a knockout model, researchers can delve into the downstream effects of FNIP2 absence, offering insights into its contribution to physiological and pathological states.
The key function of FNIP2 is its involvement in the regulation of the mTOR (mechanistic target of rapamycin) signaling pathway, a central pathway that governs cell growth and metabolism. Knockout of FNIP2 leads to altered activity within this pathway, thereby affecting cellular responses to nutrient availability and growth signals. By utilizing these knockout cell lines, researchers can elucidate the specific mechanisms by which FNIP2 influences cellular behavior, potentially revealing novel therapeutic targets for diseases such as cancer and metabolic disorders.
The scientific importance of FNIP2 knockout cell lines extends to both fundamental research and clinical applications. These models can be instrumental in drug discovery, allowing researchers to screen for compounds that may selectively target FNIP2-related pathways. Furthermore, understanding FNIP2's role could yield significant insights into tumor biology, making these knockout lines valuable in cancer research.
Compared to other gene knockout models, FNIP2 gene knockout cell lines offer a distinct advantage due to their focus on a gene implicated in multiple signaling pathways and disease states. This specificity enables a more targeted approach in research, accommodating a wide range of experimental designs and enhancing reproducibility across studies.
Ultimately, FNIP2 Gene Knockout Cell Lines stand as an indispensable asset for researchers and clinicians alike. Their unique ability to elucidate the functional significance of FNIP2, coupled with our commitment to providing high-quality, reliable biological products, underscores our expertise in delivering solutions that drive impactful scientific discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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