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FNIP1 Knockout Cell Lines

Gene: FNIP1

Official Full Name: folliculin interacting protein 1provided by HGNC

Gene Summary: This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09225 FNIP1 Knockout cell line (HeLa) Human FNIP1 1:3~1:6 Negative Online Inquiry
KO09226 FNIP1 Knockout cell line (HCT 116) Human FNIP1 1:2~1:4 Negative Online Inquiry
KO09227 FNIP1 Knockout cell line (HEK293) Human FNIP1 1:3~1:6 Negative Online Inquiry
KO09228 FNIP1 Knockout cell line (A549) Human FNIP1 1:3~1:4 Negative Online Inquiry

Background

FNIP1 Gene Knockout Cell Lines are a specialized biological product designed to facilitate the study of the FNIP1 (Folliculin Interacting Protein 1) gene, which plays a crucial role in cellular processes such as the regulation of metabolism, cell proliferation, and tumorigenesis. These cell lines are generated using advanced gene-editing technologies, specifically CRISPR/Cas9, to create targeted deletions within the FNIP1 gene, allowing researchers to investigate the downstream physiological effects and molecular pathways influenced by FNIP1 loss.

The functionality of these knockout cell lines is grounded in their ability to accurately model the genetic absence of FNIP1, enabling scientists to dissect its role in various biological processes and diseases. For example, FNIP1 has been implicated in the mTOR signaling pathway, an essential regulator of cell growth and metabolism; thus, these knockout cell lines can be invaluable for research aimed at understanding metabolic disorders and cancer biology.

From a scientific perspective, FNIP1 knockout cell lines offer significant utility in both basic research and translational applications. They provide a powerful tool for exploring the effects of FNIP1 loss on cellular metabolism, responses to nutrient availability, and the mechanisms of oncogenesis. Moreover, such models can be pivotal for screening pharmacological agents that may target FNIP1-associated pathways, making them relevant in drug discovery efforts.

What sets FNIP1 Gene Knockout Cell Lines apart from alternative products is their high specificity and reliability, coupled with the robustness of CRISPR/Cas9 technology to ensure precise gene editing. Users benefit from the extensive validation and characterization of these cell lines, which minimizes experimental variability and enhances reproducibility in research outcomes. Furthermore, the ability to easily culture these cells in various conditions allows for a wide range of experimental setups, catering to diverse research needs.

As researchers aim to uncover insights into cancer biology and metabolic diseases, FNIP1 Gene Knockout Cell Lines serve as a crucial asset, providing clarity on the role of FNIP1 in these conditions. Our company leverages years of expertise in genetic engineering and cellular biology to deliver high-quality, rigorously validated biological products, empowering the scientific community to advance research in critical areas of health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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