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FLVCR2 Knockout Cell Lines

Gene: FLVCR2

Official Full Name: FLVCR choline and putative heme transporter 2provided by HGNC

Gene Summary: This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20372 FLVCR2 Knockout cell line (HeLa) Human FLVCR2 1:3~1:6 Negative Online Inquiry
KO20373 FLVCR2 Knockout cell line (HCT 116) Human FLVCR2 1:2~1:4 Negative Online Inquiry
KO20374 FLVCR2 Knockout cell line (HEK293) Human FLVCR2 1:3~1:6 Negative Online Inquiry
KO20375 FLVCR2 Knockout cell line (A549) Human FLVCR2 1:3~1:4 Negative Online Inquiry

Background

FLVCR2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to eliminate the expression of the FLVCR2 gene. This gene plays a pivotal role in the transport of heme across cell membranes, which is essential for cellular homeostasis and myriad biological functions. By knocking out the FLVCR2 gene, researchers can study the resulting physiological and pathophysiological effects, enabling a deeper understanding of its role in heme regulation, as well as its implications in various diseases such as anemia, certain cancers, and metabolic disorders.

The mechanism of action involves targeted gene editing, typically employing CRISPR/Cas9 technology or RNA interference strategies to disrupt the coding sequence of the FLVCR2 gene. This disruption leads to a loss of function that allows researchers to investigate how the absence of FLVCR2 influences cellular processes, signaling pathways, and stress responses related to heme management. Such insights are critical for the development of therapeutic strategies against diseases where dysregulation of heme metabolism contributes to pathology.

In scientific research settings, FLVCR2 Gene Knockout Cell Lines offer immense value, particularly in pharmacological studies, toxicity assessments, and fundamental research on cellular metabolism. By utilizing these knockout lines, researchers can explore the complex network of gene functions in relation to heme synthesis and degradation, significantly contributing to the understanding of red blood cell formation and potential treatment avenues for related conditions.

One of the key advantages of FLVCR2 Gene Knockout Cell Lines over existing alternatives is the specificity and reproducibility offered by our validated gene-targeting techniques. Unlike traditional cell lines that may contain fluctuating expression levels of the gene of interest, our knockout lines provide a robust model that consistently demonstrates the complete absence of FLVCR2, thereby ensuring more reliable experimental outcomes.

This high level of precision makes FLVCR2 Gene Knockout Cell Lines an invaluable resource for researchers and clinicians looking to unravel the complexities of heme biology and its associated diseases. By choosing our product, users are assured of quality and expertise, backed by years of experience in the field of genetic engineering and cell line development. Our commitment to advancing scientific research positions us as a trusted partner in unlocking the potential of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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