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FLNC Knockout Cell Lines

Gene: FLNC

Official Full Name: filamin Cprovided by HGNC

Gene Summary: This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Mutations in this gene are a cause of cardiopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2022]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10768 FLNC Knockout cell line (HeLa) Human FLNC 1:3~1:6 Negative Online Inquiry
KO10769 FLNC Knockout cell line (HCT 116) Human FLNC 1:2~1:4 Negative Online Inquiry
KO10770 FLNC Knockout cell line (HEK293) Human FLNC 1:3~1:6 Negative Online Inquiry
KO10771 FLNC Knockout cell line (A549) Human FLNC 1:3~1:4 Negative Online Inquiry

Background

FLNC Gene Knockout Cell Lines are specialized cellular models engineered to specifically lack functional FLNC (Filamin C) genes, providing researchers with a powerful tool to study the molecular and cellular roles of this important protein. The FLNC gene encodes a crucial component of the cytoskeleton, contributing to cellular structure, motility, and signal transduction pathways. By knocking out this gene, these cell lines enable a deeper understanding of the consequences of FLNC deficiency, including its effects on myofibril organization and cellular mechanics.

The primary function of FLNC Gene Knockout Cell Lines is to serve as a baseline for comparative studies against wild-type controls, allowing researchers to investigate alterations in cellular behavior, gene expression, and signaling pathways. The mechanisms by which gene knockout induces phenotypic changes are multifaceted, often involving compensatory pathways and unique cellular stress responses that can be leveraged for therapeutic insights.

Scientific importance lies in the potential applications of these cell lines across various fields including cardiology, oncology, and muscle biology. Understanding how FLNC contributes to disease states, such as cardiomyopathies or skeletal muscle disorders, can pave the way for new treatment modalities. Moreover, these knockout lines facilitate high-throughput screening processes for drug discovery targeting related pathways.

What sets FLNC Gene Knockout Cell Lines apart from traditional cell models is their specificity and reliability. These custom-engineered lines provide a definitive approach to studying the loss of FLNC function without the confounding effects of other cellular processes, ensuring the integrity of experimental results. This specificity allows for nuanced insights that are often obscured in less targeted models.

Researchers, clinicians, and pharmaceutical companies will find significant value in utilizing these knockout cell lines, as they open avenues for innovative research and therapeutic development focusing on muscular and cardiac health. By choosing FLNC Gene Knockout Cell Lines, users invest in a reliable resource that embodies quality and scientific rigor, backed by our company’s deep expertise in CRISPR technology and cellular biology products.

Please note that all services are for research use only. Not intended for any clinical use.

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