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FKBP4 Knockout Cell Lines

Gene: FKBP4

Official Full Name: FKBP prolyl isomerase 4provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37860 FKBP4 Knockout cell line (HeLa) Human FKBP4 1:3~1:6 Negative Online Inquiry
KO37861 FKBP4 Knockout cell line (HCT 116) Human FKBP4 1:2~1:4 Negative Online Inquiry
KO37862 FKBP4 Knockout cell line (HEK293) Human FKBP4 1:3~1:6 Negative Online Inquiry
KO37863 FKBP4 Knockout cell line (A549) Human FKBP4 1:3~1:4 Negative Online Inquiry

Background

FKBP4 Gene Knockout Cell Lines are specially engineered cellular models in which the FKBP4 gene has been inactivated through targeted genomic editing. This approach leverages CRISPR-Cas9 technology or homologous recombination methods to create precise mutations, resulting in a loss of functional FKBP4 protein. FKBP4, also known as FK506-binding protein 4, is involved in several important cellular processes, including steroid hormone receptor signaling and protein folding, making it a vital area of study in physiological and pathological contexts.

The key functions of FKBP4 extend to regulating intracellular processes associated with stress responses and apoptosis. Its absence allows researchers to elucidate the gene's roles in cellular differentiation and response to endocrine signals, providing insights into diseases where this protein's function is disrupted—such as cancer and metabolic disorders. These knockout cell lines serve as critical tools in pharmacological research, enabling the examination of drug interactions and the evaluation of therapeutic targets related to FKBP4.

Scientifically, FKBP4 Gene Knockout Cell Lines are particularly relevant in fields such as oncology, endocrinology, and developmental biology. They facilitate high-throughput screening of drugs and allow for precise modeling of disease states, thereby accelerating the translation of discoveries into clinical applications. Compared to traditional models, these knockout lines provide a more accurate representation of the physiological environment due to their definitive genetic modifications.

The specific advantages of FKBP4 Gene Knockout Cell Lines lie in their reproducibility and customization for various research applications. They offer unmatched precision in experimental designs, allowing researchers to investigate the direct consequences of FKBP4 loss on cell function and signaling pathways. Furthermore, their generation is supported by cutting-edge technology that ensures high targeting efficiency and minimal off-target effects, making them superior to many existing models.

By choosing FKBP4 Gene Knockout Cell Lines, researchers and clinicians position themselves at the forefront of innovation, equipped to explore new therapeutic avenues and contributing to a more profound understanding of complex biological systems. Our company prides itself on delivering high-quality cellular models and has extensive experience in genetic engineering, ensuring that our products meet the rigorous demands of modern biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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